Phenolic Compounds Diversity of Teucrium Species

Mihailović, Vladimir; Stanković, Jelena S. Katanić; Mihailović, Nevena R.

doi:10.1007/978-3-030-52159-2_6

Cited by 8 publications

(23 citation statements)

References 53 publications

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“…Both social and cultural factors should be considered in the study of the Middle to Upper Palaeolithic transition (Mihailović 2020), especially when one takes into account the complexity of social and cultural conditions in the northern Balkans during the transition. In this period, the territory of the Balkan Peninsula was simultaneously inhabited by the makers of the late (i.e., Typical) Mousterian (Šalitrena Pećina), Charentian (Petrovaradin Fortress, Pešturina Cave), industries with leaf points (Risovača), and the initial Upper Palaeolithic (Bacho Kiro and Temnata Dupka Caves in Bulgaria etc).…”

Section: Discussionmentioning

confidence: 99%

Chronology and Succession of Palaeolithic Technocomplexes in Serbia

Mihailović,

Mihailović

2023

Зборник Народног музеја Србије. Археологија = Recueil du Musée

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During the last two decades, the state of Palaeolithic research in the Central Balkans has improved considerably. More than a hundred caves suitable for Palaeolithic settlement have been identified South of the Sava and Danube rivers, while dozens of Palaeolithic open-air sites have been documented in the regions of Šumadija and Pomoravlje. Test pit excavations have been carried out in numerous caves, and systematic excavations have been undertaken in the Balanica Cave Complex in Sićevo and in the cave site of Šalitrena Pećina near Mionica. Most of the investigated sites have been dated using various techniques (i.e., 14 C, ESR, OSL, and TL). Thanks to this research, we now have an extraordinary opportunity to look at the chronology and succession of Palaeolithic technocomplexes in the Central Balkans. The dating results show that the territory of Serbia had been inhabited for more than 400,000 years, while the identification and periodization of Palaeolithic technocomplexes provided initial insights into the cultural and demographic changes that marked the earliest prehistory in this part of Europe.

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Section: Discussionmentioning

confidence: 99%

Chronology and Succession of Palaeolithic Technocomplexes in Serbia

Mihailović,

Mihailović

2023

Зборник Народног музеја Србије. Археологија = Recueil du Musée

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“…The nutritional requirements of animals and humans for shikimate-inferred aromatic amino acids (i.e., essential amino acids) demonstrate their deficiencies in this approach [56,134]. Many naturally occurring phenolic compounds, including lignans, flavonoids, coumarins, and cinnamic acids, include the crucial C6-C3 structure of phenylpropane, which is formed from the amino acids phenylalanine and tyrosine [18,135,136]. Numerous alkaloids production begins with these amino acids and tryptophan [18,135,136].…”

Section: Biosynthesis Of Genisteinmentioning

confidence: 99%

Molecular Pathways of Genistein Activity in Breast Cancer Cells

Konstantinou,

Gioxari,

Dimitriou

et al. 2024

IJMS

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The most common malignancy in women is breast cancer. During the development of cancer, oncogenic transcription factors facilitate the overproduction of inflammatory cytokines and cell adhesion molecules. Antiapoptotic proteins are markedly upregulated in cancer cells, which promotes tumor development, metastasis, and cell survival. Promising findings have been found in studies on the cell cycle-mediated apoptosis pathway for medication development and treatment. Dietary phytoconstituents have been studied in great detail for their potential to prevent cancer by triggering the body’s defense mechanisms. The underlying mechanisms of action may be clarified by considering the role of polyphenols in important cancer signaling pathways. Phenolic acids, flavonoids, tannins, coumarins, lignans, lignins, naphthoquinones, anthraquinones, xanthones, and stilbenes are examples of natural chemicals that are being studied for potential anticancer drugs. These substances are also vital for signaling pathways. This review focuses on innovations in the study of polyphenol genistein’s effects on breast cancer cells and presents integrated chemical biology methods to harness mechanisms of action for important therapeutic advances.

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“…Some of them are widely represented in plants, while others are found only in certain families. In addition, PCs can be detected only in particular plant organs or at certain stages of ontogeny [ 22 , 23 ]. In most cases, the accumulation of PCs in aboveground organs is higher, and the composition is more diverse than in underground ones [ 24 , 25 , 26 ].…”

Section: Introductionmentioning

confidence: 99%

Effects of Hydrogen Peroxide on In Vitro Cultures of Tea (Camellia sinensis L.) Grown in the Dark and in the Light: Morphology, Content of Malondialdehyde, and Accumulation of Various Polyphenols

et al. 2022

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Tea plants (Camellia sinensis L.) are phenol-accumulating crops that are widely used for public health. The healing effect of tea leaf products is due to the biosynthesis of such phenolic compounds (PCs) as flavans, which have P-vitamin capillary-strengthening activity. Due to their limited habitat and the value of their specialized metabolites of a phenolic nature, a promising approach is to establish in vitro cultures from them that retain the ability to form PCs, which is characteristic of ex vivo tea plants. The aim of this study was to investigate the effect of exogenic H2O2 (0.01 mM; 0.1 mM; 1 mM) on the growth, morphology, degree of stress response, and accumulation of various phenolic compounds in tea plant callus cultures of different ages (24 or 36 days) grown under different cultivation conditions (darkness or light). According to the results obtained, the H2O2 effect on tea callus cultures of different ages did not cause changes in their morphophysiological characteristics, both after 2 h of exposure (rapid response of callus culture, RRCC) and after 48 h (delayed response of callus culture, DRCC). The determination of the malondialdehyde (MDA) content, which serves as an indicator of changes in the level of lipid peroxidation (LPO) and the presence of stress responses in plant cells, indicated either its maintenance at the control level, a decrease, or an increase. All these effects depended on the growth conditions of the tea callus cultures (darkness or light), their age, the duration of exposure (rapid or delayed response), and the H2O2 concentration. Similar trends were noted for the total content of PCs as well as the amount of flavans, proanthocyanidins (soluble and insoluble forms), and lignin. The plant cell responses reflected changes in its adaptation programs, when specialized metabolites act as a target for the action of H2O2, thereby contributing to an increase in their resistance.

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Phenolic Compounds Diversity of Teucrium Species

Cited by 8 publications

References 53 publications

Chronology and Succession of Palaeolithic Technocomplexes in Serbia

Chronology and Succession of Palaeolithic Technocomplexes in Serbia

Molecular Pathways of Genistein Activity in Breast Cancer Cells

Effects of Hydrogen Peroxide on In Vitro Cultures of Tea (Camellia sinensis L.) Grown in the Dark and in the Light: Morphology, Content of Malondialdehyde, and Accumulation of Various Polyphenols

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