ABSTRACT:To establish parameters for quality control of Morus alba leaves were done tests of purity by determining the loss on drying, foreign matter, total ash, acid insoluble ash, swelling index, bitterness index, yield of crude extract, pH and organoleptic properties. The tests were done with samples collected on March, June, September and December according to Brazilian Pharmacopeia and World Health Organization. The percentage of loss on drying found are according to the established value of 14 %, the highest content was on September 12.89 ± 0.1400 %. The indices of foreign matter found are agreement with the amount allowed by Brazilian Pharmacopeia, which establishes a maximum of 2 % for most of the herbal drugs. The colletc on March showed the highest content of total ash and acid insoluble ash, respectively, 20.48 ± 0.3517 % and 5.68 ± 0.1057 %. The swelling index showed higher values in samples collected on September 7.95 ± 0.2186 mL and on December 7.1 ± 0.8544 mL. The bitterness index was higher in the first two collections, 1.037 units/g in both. The yield produced was 18 % on March, 29.61 % on June, 26.47 % on September and 24.35 % on December. The pH of aqueous extract was neutral (pH 7.0) on March and slightly acid (pH 6.0) in other months. The four collect showed small variations in relation the organoleptic properties. It was done dosage of total polyphenols and flavonoids with 70% ethanol extracts of M. alba leaves. The content found of polyphenols were 6.467 ± 0,012; 5.503 ± 0.007; 6.016 ± 0.020; 6.943 ± 0.046 milligrams of gallic acid per gram of dried plant on March, June, September and December, respectively. The content of flavonoids found were 4.345 ± 0.008; 3.782 ± 0.016; 4.362 ± 0.005; 4.893 ± 0.013 milligrams of rutin per gram of dried plant.
Descriptors: Morus alba;