Phenolic Compound, Antioxidant and Antibacterial properties of Electrospun PVP Nanofiber loaded with Bassela rubra linn extract and Alginate from Sargassum sp.

Abstract

An alternative wound dressing based on nanofiber mats have been developed recently. The antioxidant and antibacterial activity play an important role in wound healing process. This study aims to combine the properties of Bassela rubra linn extract (BRLE) and Alginate from brown macroalgae into Polivynil Pyrrolidone (PVP) nanofiber using electrospinning method. Firstly, the optimization step was conducted to obtain the best operation voltage and distance. Afterwards, the nanofiber composites of PVP/BRLE/Alginate were injected into electrospinning tool in various Alginate concentrations of 1%, 2%, and 3% (w/w) respectively. The morphology of PVP nanofiber observed by Scanning Electron Microscopy (SEM) conveys that the closest distance and the highest voltage were the best. Meanwhile, the in vitro analysis through 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay and antibacterial activity to S. aureus and E. choli bacteria show a quite strong radical scavenging ability around 60% and adequate antibacterial property as good as reference a well-known material consecutively.

A Sequential Therapeutic Hydrogel With Injectability and Antibacterial Activity for Deep Burn Wounds’ Cleaning and Healing

“…Unfortunately, without injectability, insufficient coating may occur on the irregular shaped wounds with NexoBrid®. Besides, gauze ( Fang et al, 2021 ; Chen et al, 2021a ; Said et al, 2021 ), electrospun nanofiber ( Lutfi et al, 2021 ; Shahrousvand et al, 2021 ; Zhu et al, 2021 ), porous foam ( Wang et al, 2008 ; Staruch et al, 2017 ), biocompatible membrane ( Huang et al, 2021 ), microfibers ( Zhao et al, 2015 ; Yu et al, 2017 ), and hydrogels ( Soriano et al, 2020 ; Yuan et al, 2021 ; Kopecki, 2021 ) can be used as burn wound dressings today. However, most of them cannot display critical properties such as exudates which are absorbing and moisture-maintaining at the same time compared with hydrogel dressings ( Gou and Ma, 2018 ; Zhao et al, 2018 ; Gobhril and Grinstaff, 2015 ).…”