Phenolic Composition, Toxicity Potential, and Antimicrobial Activity of <i>Licania rigida</i> Benth (Chrysobalanaceae) Leaf Extracts

Morais, Leandro Vinicius Fernandes de; Luz, Jefferson Romáryo Duarte da; Nascimento, Thayse Evellyn Silva do; Azevedo, Marcelo Arrison dos Santos; Rocha, Walicyranison Plínio da Silva; Araújo-Silva, Gabriel; Ururahy, Marcela Abbott Galvão; Chaves, Guilherme Maranhão; Brandão-Neto, José; López, Jorge A.; Santos, Elizabeth Cristina Gomes dos; Almeida, Maria das Graças

doi:10.1089/jmf.2021.0059

Cited by 6 publications

(6 citation statements)

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“…In addition to synergism, the chemical compositions of AELR and HELR display concurrent antioxidant activity, which is attributed to the presence of polyphenols. This activity was previously described by Morais et al [ 16 ] and Batista et al [ 32 ], who showed high scavenging free radical DPPH capacities and reductions in lipid peroxidation by HELR and AELR, respectively. Overall, examination of these antioxidant parameters indicates potential protective effects.…”

Section: Discussionsupporting

confidence: 79%

“…Furthermore, previous studies by our group with AELR indicated no toxic effects, as evidenced by acute toxicity, 28-day repeated dose oral toxicity, cytotoxicity, and mutagenicity [ 32 ]. Regarding the hydroethanolic leaf extract, Morais et al [ 16 ] reported no toxicity in animals, no cytotoxicity, and nonsignificant apoptotic levels. This assessment is required to determine the potential health risks of natural products [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

“…However, Carnevale et al [ 21 ] reported that triterpenoids, diterpenoids, steroids, and flavonoids were the main chemical compounds in the Chrysobalanaceae family. Morais et al [ 16 ] detected significant amounts of phenolic compounds and flavonoids with flavonol-3- O -glycosylates as the main constituents in the phytochemical analysis of L. rigida hydroalcoholic leaf extract and its ethyl acetate fraction. This flavonol is likely isovitexin, which was identified in the hydroalcoholic extract in the present study, although further analyses, such as NRM, are required to confirm this finding.…”

Section: Discussionmentioning

confidence: 99%

“…Licania rigida Benth is a large evergreen tree species from the Brazilian Caatinga that is known as oiticica, and is commonly used in the treatment of inflammatory processes and diabetes [ 12 ]. This plant is traditionally used for its antimicrobial and anticancer properties, which are associated with oxidative stress [ 13 , 14 , 15 , 16 ]. Studies have evaluated the biological and pharmacological activities of plants belonging to the same family as Licania (Chrysobalanaceae) and demonstrated their anti-inflammatory effects [ 13 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

“…Several plant metabolites of L. rigida have shown pharmacological activity, including certain phenolic compounds. According to Morais et al [ 16 ], L. rigida crude leaf extract and its ethyl acetate fraction contain the flavonol- O -3 glycosylated flavonoid as its main compound. This molecule displays several biological properties, including anti-inflammatory activity and inhibitory potential against inflammatory mediators such as xanthine oxidase (XO), cyclooxygenase (COX), and lipoxygenase [ 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%

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Mass Spectrometric Identification of Licania rigida Benth Leaf Extracts and Evaluation of Their Therapeutic Effects on Lipopolysaccharide-Induced Inflammatory Response

et al. 2022

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Licania rigida Benth has been evaluated as an alternative drug to treat diseases associated with inflammatory processes. This study evaluated the anti-inflammatory effects of aqueous and hydroalcoholic leaf extracts of L. rigida with inflammation induced by lipopolysaccharides in in vitro and in vivo inflammation models. The phytochemical profile of the extracts, analyzed by ultra-fast liquid chromatography coupled with tandem mass spectrometry, revealed the presence of gallic and ellagic acids in both extracts, whereas isovitexin, ferulate, bulky amino acids (e.g., phenylalanine), pheophorbide, lactic acid, and pyridoxine were detected in the hydroalcoholic extract. The extracts displayed the ability to modulate in vitro and in vivo inflammatory responses, reducing approximately 50% of pro-inflammatory cytokine secretion (TNF-α, IL-1β, and IL-6), and inhibiting both NO production and leukocyte migration by approximately 30 and 40% at 100 and 500 µg/mL, respectively. Overall, the results highlight and identify, for the first time, the ability of L. rigida leaf extract to modulate inflammatory processes. These data suggest that the leaf extracts of this plant have potential in the development of herbal formulations for the treatment of inflammation.

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Section: Discussionsupporting

confidence: 79%