Phenolic composition of grape pomace and its metabolism

Yang, Chao; Han, Yulei; Tian, Xuelin; Sajid, Marina; Mehmood, Sajid; Wang, Hua; Li, Hua

doi:10.1080/10408398.2022.2146048

Cited by 24 publications

(27 citation statements)

References 120 publications

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“…They could exert antioxidant effects along the storage, where their content was reported to increase (Li et al ., 2022). The polymerisation of some compounds may be another responsible for this bioactivity as well as the antioxidant fibre present in these SGPs (Yang et al ., 2022).…”

Section: Resultsmentioning

confidence: 99%

“…The best inhibition was found after 1 month (IC 50 of 74.76 ± 0.05 mg/mL). This behaviour is correlated with the content of gallic acid [ r = 0.7856 ( P < 0.05)] and epicatechin [ r = 0.7612 ( P < 0.05)], maybe due to the polymerisation of these compounds along the time (Yang et al ., 2022). In addition, a correlation of 58.43% ( P < 0.05) was found with the AOA, suggesting the presence of other molecules than phenolic compounds involved in this bioactivity.…”

Section: Resultsmentioning

confidence: 99%

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Monitoring of the use of spent grape pomace after industrial distillation as a potent antioxidant and enzymes inhibitor

Cisneros‐Yupanqui,

Rizzi,

Mihaylova

et al. 2023

Int J of Food Sci Tech

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SummarySpent grape pomace (SGP) obtained after the production of Grappa has been recognized as a source of antioxidant bioactive compounds. This paper aimed to assess the antioxidant activity and inhibitory effects on enzymes related to non‐communicable diseases of white and red SGP, as well as to monitor the impact of storage on these bioactivities. In both pomaces, distillation did not preserve some of the bioactivities; however, after one month of storage there was an improvement. The phenolic profile remained relatively stable during storage while the inhibition of α‐glucosidase (AG) was improved. These results confirmed the remaining bioactivity of SGP, demonstrating its potential use in the food industry.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Monitoring of the use of spent grape pomace after industrial distillation as a potent antioxidant and enzymes inhibitor

Cisneros‐Yupanqui,

Rizzi,

Mihaylova

et al. 2023

Int J of Food Sci Tech

View full text Add to dashboard Cite

show abstract

“…Kang et al (2009) further developed methods of synthesis for preparing resveratrol derivatives and analogues. 102 A Merrifield chloromethylstyrene resin (1) was bonded covalently to 4-hydroxybenzaldehyde (2), which was reacted with a Grignard reagent to shape a secondary alcohol (4). The substituted phosphonium ion (5) was produced by the secondary alcohol (4) for coupling with a second aryl aldehyde (6) through the Witting reaction.…”

Section: Condensation Reactionmentioning

confidence: 99%

“…Stilbenes are a group of nonflavonoid polyphenolic compounds with a basic 1,2-diphenylethylene skeleton as parent nuclei, widely present in many traditional herbs and in a few fruits such as grapes and berries. , Stilbenes, as a secondary metabolite are phytoalexins, produced in the process of plant growth to defend against pathogen attacks and other stresses. Natural stilbenes are mainly a complex class of biodiverse compounds formed by oxidation, methylation, glycosylation, isomerization, methoxylation, and polymerization.…”

Section: Introductionmentioning

confidence: 99%

Trends in the Potential of Stilbenes to Improve Plant Stress Tolerance: Insights of Plant Defense Mechanisms in Response to Biotic and Abiotic Stressors

Gao,

Zheng,

et al. 2024

J. Agric. Food Chem.

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Stilbenes belong to the naturally synthesized plant phytoalexins, produced de novo in response to various biotic and abiotic stressors. The importance of stilbenes in plant resistance to stress and disease is of increasing interest. However, the defense mechanisms and potential of stilbenes to improve plant stress tolerance have not been thoroughly reviewed. This work overviewed the pentose phosphate pathway, glycolysis pathway, shikimate pathway, and phenylalanine pathway occurred in the synthesis of stilbenes when plants are subjected to biotic and abiotic stresses. The positive implications and underlying mechanisms regarding defensive properties of stilbenes were demonstrated. Ten biomimetic chemosynthesis methods can underpin the potential of stilbenes to improve plant stress tolerance. The prospects for the application of stilbenes in agriculture, food, cosmetics, and pharmaceuticals industries are anticipated. It is hoped that some of the detailed ideas and practices may contribute to the development of stilbene-related products and improvement of plant resistance breeding.

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“…Nevertheless, in a certain way, it can be said that this activity of GP as a cardiometabolic health-promoting ingredient would begin in the gastrointestinal tract as GP components (i.e., (poly)phenols and fiber) undergo extensive catabolism, mainly by the action of the intestinal microbiota, that gives rise to low-molecular-weight bioactive compounds that can be absorbed and utilized by the body [ 20 ]. Dietary (poly)phenols are metabolized by the gut microbiota and concentrated in the gut lumen, reaching biologically relevant concentrations that allow them to exert local beneficial effects [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Grape Pomace as a Cardiometabolic Health-Promoting Ingredient: Activity in the Intestinal Environment

et al. 2023

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Grape pomace (GP) is a winemaking by-product particularly rich in (poly)phenols and dietary fiber, which are the main active compounds responsible for its health-promoting effects. These components and their metabolites generated at the intestinal level have been shown to play an important role in promoting health locally and systemically. This review focuses on the potential bioactivities of GP in the intestinal environment, which is the primary site of interaction for food components and their biological activities. These mechanisms include (i) regulation of nutrient digestion and absorption (GP has been shown to inhibit enzymes such as α-amylase and α-glucosidase, protease, and lipase, which can help to reduce blood glucose and lipid levels, and to modulate the expression of intestinal transporters, which can also help to regulate nutrient absorption); (ii) modulation of gut hormone levels and satiety (GP stimulates GLP-1, PYY, CCK, ghrelin, and GIP release, which can help to regulate appetite and satiety); (iii) reinforcement of gut morphology (including the crypt-villi structures, which can improve nutrient absorption and protect against intestinal damage); (iv) protection of intestinal barrier integrity (through tight junctions and paracellular transport); (v) modulation of inflammation and oxidative stress triggered by NF-kB and Nrf2 signaling pathways; and (vi) impact on gut microbiota composition and functionality (leading to increased production of SCFAs and decreased production of LPS). The overall effect of GP within the gut environment reinforces the intestinal function as the first line of defense against multiple disorders, including those impacting cardiometabolic health. Future research on GP’s health-promoting properties should consider connections between the gut and other organs, including the gut-heart axis, gut-brain axis, gut-skin axis, and oral-gut axis. Further exploration of these connections, including more human studies, will solidify GP’s role as a cardiometabolic health-promoting ingredient and contribute to the prevention and management of cardiovascular diseases.

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Phenolic composition of grape pomace and its metabolism

Cited by 24 publications

References 120 publications

Monitoring of the use of spent grape pomace after industrial distillation as a potent antioxidant and enzymes inhibitor

Monitoring of the use of spent grape pomace after industrial distillation as a potent antioxidant and enzymes inhibitor

Trends in the Potential of Stilbenes to Improve Plant Stress Tolerance: Insights of Plant Defense Mechanisms in Response to Biotic and Abiotic Stressors

Grape Pomace as a Cardiometabolic Health-Promoting Ingredient: Activity in the Intestinal Environment

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