Phenolic Antioxidant Capacity: A Review of the State of the Art

Miguel-Chávez, Rubén San

doi:10.5772/66897

Cited by 60 publications

(52 citation statements)

References 48 publications

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“…Its importance lies in its participation in physiological processes, cellular metabolism, growth, reproduction, germination processes, as well as defense against pests and predators, among others [21][22][23]. Recent studies [24,25], have demonstrated their significant antioxidant activity [21], which may be beneficial to human health [26]. The antioxidant capacity of polyphenols, produced by cellular metabolism, is due to the capture and inactivation of free radicals and reactive oxygen species (ROS) [27].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Silver Nanoparticles Using Aqueous Leaf Extract of Mimosa albida (Mimosoideae): Characterization and Antioxidant Activity

et al. 2020

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The search for sensitive and rapid analytical techniques for the determination of natural antioxidants is an area in constant growth due, among other aspects, to the complexity of plant matrices. In this study, silver nanoparticles prepared with the aqueous extract of Mimosa albida leaves were used to assess their polyphenolic content and antioxidant capacity. Silver nanoparticles were characterized by different techniques. As a result, nanoparticles of 6.5 ± 3.1 nm were obtained. The total phenolic content in the extract was 1320.4 ± 17.6 mg of gallic acid equivalents GAE· 100 g−1 and in the nanoparticles 257.3 ± 5.1 mg GAE· 100 g−1. From the phenolic profile analyzed by ultra high-performance liquid chromatography (UPLC) with a diode-array detector (DAD), the presence of apigenin and luteolin in the plant extract is postulated. The antioxidant capacity measured by oxygen radical absorbance capacity ORAC-fluorescein assay was 86917 ± 6287 and 7563 ± 967 µmol ET g−1 in the extract and nanoparticles respectively. Electrochemical analysis by cyclic voltammetry (CV) confirmed the effective reduction capacity of the Mimosa albida leaves extract to reduce Ag ions to AgNPs and differential pulse voltammetry (DPV) suggested the presence of two main reducing agents in the extract. From this study, it was concluded that the aqueous extract of Mimosa albida contains reducing agents capable of synthesizing silver nanoparticles, which can be used in the phytochemical industry.

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Section: Introductionmentioning

confidence: 99%

Synthesis of Silver Nanoparticles Using Aqueous Leaf Extract of Mimosa albida (Mimosoideae): Characterization and Antioxidant Activity

et al. 2020

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“…The ABTS method was performed because tested compounds contain either 4-aminophenol or hydroxystilbene or hydroxychalcone structural moieties. Currently, the ABTS method is one of the most widely used for the determination of the antioxidative properties of phenols [14]. We assumed that the mechanism of action is probably very similar to resveratrol and analogous compounds.…”

Section: Resultsmentioning

confidence: 99%

“…For example, Nageshi et al synthesized very effective antioxidants based on the structure of chalcones and containing phenolic functional group (Figure 1e) [13]. Phenolic compounds are one of the largest groups of antioxidants with high activity [1,4,[7][8][9]14]. An example of phenolic antioxidant, which is used in medicine as an adjuvant treatment of cardiovascular diseases, metabolic syndrome, type 2 diabetes, and inflammatory diseases, is resveratrol (stilbene derivative, Figure 1f) [4].…”

Section: Introductionmentioning

confidence: 99%

New 1,3,5-Triazine Derivatives Incorporating Aminobenzenesulfonamide, Aminoalcohol, Piperazine, Chalcone or Stilbene Structural Motifs and Evaluation of Their Antioxidative Activity

Havránková

Čalkovská

Padrtova

et al. 2019

The 23rd International Electronic Conference on Synthetic Organic Chemistry

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A series of 1,3,5-triazine derivatives, incorporating aminobenzenesulfonamide, aminoalcohol/phenol, piperazine, chalcone, or stilbene structural motifs, were evaluated as potential antioxidants. The compounds were prepared by using step by step nucleophilic substitution of chlorine atoms in starting 2,4,6-trichloro-1,3,5-triazine. Reactions were catalyzed by Cu(I)-supported on a weakly acidic resin. The radical scavenging activity was determined in terms of %inhibition activity and IC50, using the ABTS method. Trolox and ascorbic acid (ASA) were used as standards. In the lowest used concentration 1 × 10 −4 M, the %inhibition activity at time 0 min was comparable with both standards at least for 10 compounds. After 60 min compounds 1, 2, 9 and 25 showed nearly twice %inhibition (73.44-87.09%) in comparison with standards (Trolox = 41.49%; ASA = 31.07%). Values of IC50 correlated with %inhibition activity . For compounds 1, 2, 9 and 25 values of IC50 in time 60 min (17.16-27.78 μM) were 5 times lower than IC50 of both standards (Trolox = 178.33 μM; ASA = 147.47 μM). Based on these results, the presented 1,3,5-triazine derivatives and their analogs have a high potential in the treatment of illnesses caused or related to oxidative stress.

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“…This information is not unexpected as DCM extract displayed less phenolic content. One or more than one hydroxyl group are attached to the benzene ring, and this structural quality is responsible for its antioxidant potential [26]. Amazingly, the previous studies revealed that higher DPPH scavenging activity is related to the presence of high phenolic content [9,27,28].…”

Section: Antioxidant Potentialmentioning

confidence: 99%

Secondary Metabolites Profiling, Biological Activities and Computational Studies of Abutilon figarianum Webb (Malvaceae)

et al. 2020

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This research endeavors to inspect the chemical and biological profiling of methanol and dichloromethane (DCM) extracts prepared from Abutilon figarianum Webb. Total bioactive constituents and secondary metabolites were assessed via ultra-high performance liquid chromatography (UHPLC-MS). Biological effects were evaluated via antioxidant and enzymes inhibitory assays. The methanol extract was able to give the highest phenolic (51.92 mg GAE/g extract) and flavonoid (72.59 mg QE/g extract) contents and was found to contain 11 bioactive metabolites, including flavonoid, alkaloid, phenolic and fatty acid derivatives, as accessed by UHPLC-MS analysis. Similarly, the phytochemical profiling of the DCM extract tentatively identified the 12 different secondary metabolites, most of these were fatty acid derivatives. The methanol extract was most active in the radical scavenging, reducing power and total antioxidant power assays, while dichloromethane extract showed the highest metal chelating activity. For enzyme inhibition, the DCM extract showed the highest activity against cholinesterases, glucosidase and amylase, whereas methanol extract was most active against tyrosinase. Docking studies have supported the observed biological activity, where isobergapten showed higher activity against tyrosinase (−7.63 kcal/mol) with inhibition constant (2.55 µM), as opposed to other enzymes. The observed antioxidant and inhibitory potentials of A. figarianum against the studied enzymes tend to endorse this plant as a prospective source of bioactive phytochemicals.

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Phenolic Antioxidant Capacity: A Review of the State of the Art

Cited by 60 publications

References 48 publications

Synthesis of Silver Nanoparticles Using Aqueous Leaf Extract of Mimosa albida (Mimosoideae): Characterization and Antioxidant Activity

Synthesis of Silver Nanoparticles Using Aqueous Leaf Extract of Mimosa albida (Mimosoideae): Characterization and Antioxidant Activity

New 1,3,5-Triazine Derivatives Incorporating Aminobenzenesulfonamide, Aminoalcohol, Piperazine, Chalcone or Stilbene Structural Motifs and Evaluation of Their Antioxidative Activity

Secondary Metabolites Profiling, Biological Activities and Computational Studies of Abutilon figarianum Webb (Malvaceae)

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