Phenolamide extract of apricot bee pollen alleviates glucolipid metabolic disorders and modulates the gut microbiota and metabolites in high-fat diet-induced obese mice

Abstract

Phenolamide alleviates glucolipid metabolic disorders and modulates gut microbiota and metabolites in high-fat diet-induced obese mice.

New Insights into Identification, Distribution, and Health Benefits of Polyamines and Their Derivatives

“…Hydroxycinnamic acids usually present cis–trans isomers, thus resulting in multiple isomers of CPAs, such as tri- p -coumaroyl spermidine isomers in Lycium berry and bee pollen. , Generally, HRMS is unable to differentiate between cis and trans isomers. In recent years, Seon Beom Kim and his colleagues have identified some cis–trans isomers of CPAs through nuclear magnetic resonance (NMR) spectroscopy.…”

“…There is relatively limited research concerning the modulation of gut microbiota by CPAs. Recently, research indicated that CPAs (especially tri- p -coumaroyl spermidine) from apricot bee pollen can counteract the elevation in the Firmicutes/Bacteroidetes ratio observed in mice fed an HFD . Furthermore, CPAs promoted the proliferation of beneficial bacteria like Muribaculaceae and Parabacteroides while concurrently diminishing the presence of detrimental bacteria such as Peptostreptococcaceae and Romboutsia .…”

“…Moreover, Zhang et al investigated the effect of phenolamide extract from apricot bee pollen on obese mice fed a high-fat diet (HFD) . The results demonstrate that apricot bee pollen extract containing 87.75% CPAs (tri- p -coumaroyl spermidine as the dominant compound) exhibits the capacity to significantly decrease hepatic and epididymal fat lipid accumulation, enhance glucose tolerance, mitigate insulin resistance, and ameliorate lipid metabolism in mice subjected to a high-fat diet (HFD).…”

“…Recently, research indicated that CPAs (especially tri-p-coumaroyl spermidine) from apricot bee pollen can counteract the elevation in the Firmicutes/Bacteroidetes ratio observed in mice fed an HFD. 17 Furthermore, CPAs promoted the proliferation of beneficial bacteria like Muribaculaceae and Parabacteroides while concurrently diminishing the presence of detrimental bacteria such as Peptostreptococcaceae and Romboutsia. 17 This indicates that CPAs can regulate gut microbiota, a potentially pivotal avenue for research into the function of CPAs.…”

“…In recent years, with the ongoing advancement of research on polyamines in food, there has been a continuous update of reviews on the types, quantities, and potential benefits of polyamines in food. ,,,− However, previous reviews’ attention toward polyamines in food has been predominantly centered on the free form, while less attention is paid to the conjugated form with a wider variety of types, quantities, and potential benefits. To the best of our knowledge, extant literature solely encompasses the review by Wang et al elucidating the chemical structures and functionalities of CPAs within food matrices .…”