Phenol-like group functionalized graphene quantum dots structurally mimicking natural antioxidants for highly efficient acute kidney injury treatment

Wang, Huan; Yu, Dongqin; Jiao, Fang; Zhou, Ya; Li, Daowei; Liu, Zhen; Ren, Jinsong; Qu, Xiaogang

doi:10.1039/d0sc03246h

Cited by 59 publications

(43 citation statements)

References 49 publications

(64 reference statements)

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“…The most interesting result is the antioxidant capacity of G-RS/T1, which displays the highest ORAC value of all four compounds: 308 μmolTE/g. It is likely that the antioxidant activity is amplified by the presence of graphene [ 42 , 43 ]. On the contrary, the low ORAC value obtained for G-RS/T10 is due to the partial insoluble nature of this compound in the hydrophilic buffer, which could underestimate the result.…”

Section: Resultsmentioning

confidence: 99%

Stretchable, Bio-Compatible, Antioxidant and Self-Powering Adhesives from Soluble Silk Fibroin and Vegetal Polyphenols Exfoliated Graphite

et al. 2021

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The development of bio-glues is still a challenging task, regarding adhesion on wet surfaces; often, high performance and adaption to complex geometries need to be combined in one material. Here, we report biocompatible adhesives obtained by blending regenerated silk (RS) with a soluble plant-derived polyphenol (i.e., chestnut tannin) that was also used to exfoliate graphite to obtain graphene-based RS/tannin (G-RS/T) composites. The resultant G-RS/T hybrid material exhibited outstanding stretchability (i.e., 400%) and high shear strength (i.e., 180 kPa), superior to that of commercial bio-glues, and showed sealant properties for tissue approximation. Moreover, we showed how such nanocomposites exhibit electromechanical properties that could potentially be used for the realization of green and eco-friendly piezoelectric devices. Finally, we demonstrate the in vitro glue’s biocompatibility and anti-oxidant properties that enable their utilization in clinical applications.

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Section: Resultsmentioning

confidence: 99%

Stretchable, Bio-Compatible, Antioxidant and Self-Powering Adhesives from Soluble Silk Fibroin and Vegetal Polyphenols Exfoliated Graphite

et al. 2021

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“…However, the delivery of drugs to renal tubules by nanodelivery systems is challenged by the glomerular filtration barrier (GFB) as most of nanocarriers possessed a large size than GFB (5.5 nm) and thus are non-specifically taken up by the mononuclear phagocyte system, leading to poor renal accumulation and high biotoxicity. Alternatively, ultrasmall nanozymes with high renal accumulation and both antioxidative and anti-inflammatory activities have arisen as promising candidates for AKI alleviation 38 - 42 . Compared with small molecular drugs, these ultrasmall nanozymes with reasonable sizes can remain in the kidneys for a longer period and have better renal specificity.…”

Section: Introductionmentioning

confidence: 99%

Clinically translatable gold nanozymes with broad spectrum antioxidant and anti-inflammatory activity for alleviating acute kidney injury

Zhang

Younis

et al. 2021

Theranostics

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Rationale: Acute kidney injury (AKI) is associated with aberrant generation of oxidative species and inflammation, leading to high mortality of in-hospitalized patients. Although N -acetylcysteine (NAC) showed positive effects in alleviating contrast-induced AKI, the clinical applications are strongly restrained due to the low bioavailability, low renal accumulation, short renal retention time, and high dosage-induced toxicity. Methods: We addressed the clinical dilemma of NAC by developing ultrasmall gold nanoclusters (1-2 nm) capped with NAC (denoted as Au NCs-NAC) as a nanozyme-based antioxidant defense system for AKI alleviation. Rhabdomyolysis-induced AKI mice model was developed, and the same dose of free NAC (as a control) and NAC onto Au NCs (Au NCs-NAC) was used for in vivo investigation of AKI restoration. Results: The as-developed gold nanozyme exhibited high bioavailability and good physicochemical stability as compared to NAC. Meanwhile, Au NCs-NAC showed broad-spectrum antioxidant activity of Au NCs-NAC, offering in vitro renoprotective effects, as well as macrophages by relieving inflammation under hydrogen peroxide or lipopolysaccharide stimulation. Notably, owing to the smaller size than kidney threshold (5.5 nm), Au NCs-NAC displayed preferential renal enrichment (< 2 h) and longer retention (> 24 h) in AKI mice as revealed by fluorescence imaging, thereby largely enhancing the restoration of renal function in AKI mice than free NAC by protecting the kidneys from oxidative injury and inflammation without systemic toxicity, as demonstrated by tissues staining, inflammatory cytokines and biomarkers detection, and mice survival rate. Conclusion: Owing to the synergistic anti-inflammatory/antioxidative effects, and enhanced bioavailability and renal accumulation/retention, Au NCs-NAC displayed far superior therapeutic performance than NAC alone. This work will facilitate the development of high-performance antioxidative nanoplatforms, as well as overcome the clinical limitations of small molecular drugs for AKI treatment and other inflammatory diseases.

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“…It has been proven in the previous literature that polyphenol-based materials could effectively achieve passive accumulation in the kidney and long renal retention. 56 The kidney and blood serum samples were collected at 24 h after model establishment to further assess the kidney function. In the clinic, blood urea nitrogen (BUN) and serum creatinine (CRE) are widely used to evaluate the kidney function.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…Two hours after glycerol injection, GNP-5 was intravenously injected into the mice and normal saline was injected in the other group as the control one. It has been proven in the previous literature that polyphenol-based materials could effectively achieve passive accumulation in the kidney and long renal retention . The kidney and blood serum samples were collected at 24 h after model establishment to further assess the kidney function.…”

Section: Results and Discussionmentioning

confidence: 99%

Green Nanoparticle Scavengers against Oxidative Stress

Yang

Zhang

Xiang

et al. 2021

ACS Appl. Mater. Interfaces

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The usage of exogenous antioxidant materials to relieve oxidative stress offers an important strategy for the therapy of oxidative stress-induced injuries. However, the fabrication processes toward the antioxidant materials usually require the involvement of extra metal ions and organic agents, as well as sophisticated purification steps, which might cause tremendous environmental stress and induce unpredictable side effects in vivo. To address these issues, herein, we proposed a novel strategy to fabricate green nanoparticles for efficiently modulating oxidative stress, which was facilely prepared from tea polyphenol extracts (originated from green tea) via a green enzymatic polymerization-based chemistry method. The resulting nanoparticles possessed a uniform spherical morphology and good stability in water and biomedium and demonstrated excellent radical scavenging properties. These nanoparticle scavengers could effectively prevent intracellular oxidative damage, accelerate wound recovery, and protect the kidneys from reactive oxygen species damaging in the acute kidney injury model. We hope this work will inspire the further development of more types of green nanoparticles for antioxidant therapies via similar synthetic strategies using green biomass materials.

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Phenol-like group functionalized graphene quantum dots structurally mimicking natural antioxidants for highly efficient acute kidney injury treatment

Abstract: Acute kidney injury (AKI) is a syndrome characterized by rapid loss of renal excretory function with high in-hospital mortality. The excess generation of reactive oxygen species (ROS) in kidneys during...

Cited by 59 publications

References 49 publications

Stretchable, Bio-Compatible, Antioxidant and Self-Powering Adhesives from Soluble Silk Fibroin and Vegetal Polyphenols Exfoliated Graphite

Stretchable, Bio-Compatible, Antioxidant and Self-Powering Adhesives from Soluble Silk Fibroin and Vegetal Polyphenols Exfoliated Graphite

Clinically translatable gold nanozymes with broad spectrum antioxidant and anti-inflammatory activity for alleviating acute kidney injury

Green Nanoparticle Scavengers against Oxidative Stress

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