Phenol derivatized hexahydropyrimidines prepared from Mannich condensations

Synthesis of amine-phenol ligands in water – a simple demonstration of a hydrophobic effect

“…Care must be taken to use the correct relative stoichiometries in this reaction as alternative products, such as a diaminotetraphenol or a diaminebis(phenol), can form (5c,6j,10). The syntheses of 4a,b are also of interest as they proceed via a disfavored five-endo-trig ring closure (11). The coordination of this recently discovered more rigid ligand-set has so far been limited to ytterbium (4d), but given the large, inflexible bite angle between the two phenol donors it is likely to show diverse chemistry with other lanthanides and larger transition metals, e.g., zirconium and hafnium.…”

Amine‐bridged bis(phenol) ligands for efficient Pd‐catalyzed aqueous C‐C coupling reactions

“…All chemicals employed in the synthesis were analytical grade, obtained commercially, and used as received without further purification. Ligands 1 , 2 and 3 were prepared as reported. NMR spectra were performed on a Bruker Avance III 400 MHz spectrometer (tetramethylsilane as internal standard) and coupling constants ( J values) are given in hertz.…”

“…The development of amine‐bridged bis(phenol) ligands that have a rigid framework with bulky N ‐aryl substituents on the ring nitrogen to restrict the rotation of the coordination group has rarely been explored . The presence of the nitrogen atom on the amine bridge seems to have a significant effect on the catalytic activity of the corresponding ligands .…”

N,N,N′,N′-Tetrakis(2-hydroxy-5-methylbenzyl)ethane-1,2-diamine dimethylformamide disolvate

“…Multidentate aminophenol are of interest as metallochelators and as ligands for bioinorganic modeling, catalysis, and medical imaging. (Higham et al, 2006;Farrell et al, 2007). Some of them in combination with metals are used as active catalysts for alkenes polymerization (Tshuva et al, 2000) and initiators in the ring-openingpolymerization of lactones (Liu et al, 2007).…”