Phenol–croton oil peel enhances type‐1 and type‐3 collagen amounts by stimulating SIRT‐6 and SIRT‐7

Abstract

Phenol-croton oil peel enhances type-1 and type-3 collagen amounts by stimulating SIRT-6 and SIRT-7Dear Editor, Adults lose 1% of collagen per year because of aging. 1This process impacts negatively more on type-3 (COL3) than type-1 (COL1) collagen and is aggravated by metalloproteinases and photoaging-decreased neocollagenesis. 2Sirtuins (SIRT), a histone-deacetylase family, cause longevity of fibroblasts and regulate collagen synthesis. 3 SIRT protect skin against UV-dependent damage by repairing DNA, controlling inflammation, and modulating antioxidant defense. 4 SIRT-1,

Updates on level of evidence of clinical efficacy of facial phenol‐croton oil peels and comments on history and mechanisms of action

“…The COVID-19 Dermatology Registry, an international registry created through a collaboration between the American Academy of Dermatology and the International League of Dermatologic Societies, 1…”

“…Updates on level of evidence of clinical efficacy of facial phenol-croton oil peels and comments on history and mechanisms of action Dear Editor, Cardoso et al 1 contributed with a well-designed clinical trial on the efficacy of phenol-croton oil peels for photoaging Glogau Scale III-IV. Eighty-seven percent of the 30 female subjects achieved considerable rejuvenation 3 months post-procedure (reaching Glogau I-II) with Hetter's 1.2% croton oil/35% phenol peel.…”

“…2 Another split-face trial 3 comparing the Baker's classical peel (2.1% croton oil/50% phenol) with Hetter's medium-heavy peel (0.7% croton oil/33% phenol) of the "Heresy" formulas (1996) showed that while both formulas had similar efficacy in seven female subjects, the Hetter's formula had fewer side effects. Hetter's "Heresy" Formulas (1996) still used "drops" as the measuring system for the surfactant and croton oil and introduced words to describe on the final concentration of croton oil in each formula, 4 as follows: "very light peel formula," "medium-light peel formula," "medium-heavy peel formula," "heavy peel formula," and "heaviest peel formula (Baker-Gordon)" 5 ; in 2000, the formulas were standardized to the metric system, and with fixed volume and phenol concentration to 35%, 4 with the adoption of Hetter's stock solution to facilitate measurement in milliliters by the use of syringes, as used in the trials by Cardoso et al 1 and Neitzke et al 2 Animal model experiments found similar exuberant neocollagenesis. Biopsies at 21 days after Hetter's 1.6% croton oil/35% phenol peel showed increased expression of type III collagen compared to type I collagen.…”