2001
DOI: 10.1016/s0378-4274(01)00349-6
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Phenobarbitone – induced liver response in wild type and in p53 deficient mice

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Cited by 4 publications
(5 citation statements)
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“…We observed hypertrophy of hepatocytes around the central vein (Fig. 2) as previously noticed after long term administration of phenobarbital (Anon, 2000;Berman et al, 1983;Gould et al, 2001). Mild (grade 2) to moderate (grade 3) centrilobular hypertrophy was present in all animals.…”
Section: Immunohistochemical Analysis Of Treated Rat Liversupporting
confidence: 81%
See 1 more Smart Citation
“…We observed hypertrophy of hepatocytes around the central vein (Fig. 2) as previously noticed after long term administration of phenobarbital (Anon, 2000;Berman et al, 1983;Gould et al, 2001). Mild (grade 2) to moderate (grade 3) centrilobular hypertrophy was present in all animals.…”
Section: Immunohistochemical Analysis Of Treated Rat Liversupporting
confidence: 81%
“…Therefore, phenobarbital is able to amplify cells that have been initiated in response to a carcinogen leading to tumors (Peraino et al, 1971;Peraino et al, 1973). In contrast, phenobarbital alone does not cause liver tumors in rats (Anon, 2000;Gould et al, 2001). In the present study, rats were fed CPA for two consecutive days and injected with retroviral vectors containing a h-galactosidase gene to specifically label the population of hepatocytes stimulated by the mitogenic activity of CPA.…”
Section: Introductionmentioning
confidence: 91%
“…In pathological situations, animal cells may proliferate without a need for compensation for cell loss, resulting in hyperplasia, which is a pathological phraseology for the existence of extra (redundant) cells, usually with enlargement of the affected organ as a sequel. For example, some chemicals such as phenobarbital [ 62 , 63 ] or lead nitrate [ 64 ] can induce proliferation of hepatocytes, resulting in liver enlargement [ 41 ]. Aberrant expression or mutation of some genes, usually oncogenes, may also coerce the affected cells to replicate directly [ 55 ].…”
Section: Introductionmentioning
confidence: 99%
“…Previous studies reported that no obvious abnormal liver histology was found with short-term deletion of p53; in contrast, deletion of p53 induces liver cancer after 10-12 months in mouse model(53). Several studies showed that loss of p53 did not significantly accelerate phenobarbitone or diethylnitrosamine-induced hepatocellular carcinoma(54-56). Thus, our finding suggests an important connection between p53 and Hippo pathway, two key pathways for maintaining quiescence of hepatocytes.…”
Section: Discussionmentioning
confidence: 99%