Phenobarbital Depression of Hepatic Microsomal Benzo[a]pyrene Hydroxylation in Rats Starved and Refed a Diet Containing Menhaden Fish Oil: Substrate and Fat Level Dependency
Abstract:The influence of phenobarbital on the activity of hepatic mixed function oxidases responsible for benzo[a]pyrene hydroxylation was studied in rats fed diets containing menhaden fish oil (rich in n-3 fatty acids). Male rats were starved for 2 days and refed diet devoid of fat or containing 0.5, 10, or 20% menhaden oil for 4 days. Phenobarbital increased the apparent Km value as well as Vmax for benzo[a]pyrene hydroxylase in microsomes from rats fed the 20% menhaden oil diet. The increased … Show more
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