Phenobarbital blockade of the preovulatory luteinizing hormone surge: association with phase-advanced circadian clock and altered suprachiasmatic nucleus <i>Period1</i> gene expression

Legan, Sandra J.; Donoghue, Kathleen M.; Franklin, Kathleen M.; Duncan, Marilyn J.

doi:10.1152/ajpregu.90914.2008

Cited by 15 publications

(20 citation statements)

References 63 publications

(102 reference statements)

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“…Propofol, GABA agonist, exerts an inhibitory effect on Per1 and Per2 gene expression in the SCN and advances the circadian rhythm (Ehlen et al, 2006;Legan et al, 2009). The benzodiazepine midazolam has been used as an intravenous anesthetic, and the mechanisms of action of benzodiazepines and general anesthetics may be similar with respect to circadian rhythm.…”

Section: Discussionmentioning

confidence: 99%

2,2,2-Tribromoethanol Phase-Shifts the Circadian Rhythm of the Liver Clock in Per2::Luciferase Knockin Mice: Lack of Dependence on Anesthetic Activity

Kubo

Tahara²,

Hirao³

et al. 2011

J Pharmacol Exp Ther

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Comprehensive gene expression profiling in mice in response to the inhalation of sevoflurane has revealed that circadian clock gene expression is affected strongly in the liver, heart, lung, and kidney, in this order, but moderately in the spleen and slightly in the brain. Therefore, we examined whether the administration of general anesthetics at different times of the day induces phase shifts of the liver clock in Per2::Luciferase knockin mice. One to 4 days of intraperitoneal injection of 2,2,2-tribromoethanol (240 mg/kg, anesthetic time 60 min) or 2,2,2-trichloroethanol (240 mg/kg, 60 min), common anesthetics in veterinary surgery, caused phase delays when injected during the daytime and phase advances when injected during the nighttime. Inhalation administration of isoflurane for 30 or 60 min during the daytime did not induce a phase delay. Injection of propofol (300 mg/kg, 17 min) during the daytime induced an insignificant phase delay of the Per2 bioluminescence rhythm. Injection of 2,2,2-tribromoethanol did not induce a phase shift in the suprachiasmatic nucleus, the main oscillator, or in behavioral locomotor rhythms, suggesting that 2,2,2-tribromoethanol induced phase shifts of the liver clock independent of the main suprachiasmatic clock. The expression of clock genes, such as Bmal1 and Clock, in mouse liver was decreased strongly 1 and 4 h after a single injection of 2,2,2-tribromoethanol. These results demonstrate that 2,2,2-tribromoethanol or 2,2,2-trichloroethanol produce phase shifts of the peripheral clock, independent of anesthetic activity. These anesthetics may cause circadian rhythm disorders in peripheral organs when administered as general anesthetics several times during the day.

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Section: Discussionmentioning

confidence: 99%

2,2,2-Tribromoethanol Phase-Shifts the Circadian Rhythm of the Liver Clock in Per2::Luciferase Knockin Mice: Lack of Dependence on Anesthetic Activity

Kubo

Tahara²,

Hirao³

et al. 2011

J Pharmacol Exp Ther

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“…Throughout the study, either a male hamster or soiled male hamster bedding (changed weekly) was located within several feet of each female hamster’s cage. To establish that the females were having regular estrous cycles, estrous discharges were evaluated daily as described previously (Orsini, 1961; Legan et al, 2009) until 3 consecutive estrous discharges were observed at 4-day intervals, and afterwards they were inspected every 4 th day on the expected day of estrus. Once regular estrous cyclicity was established, the hamsters were placed in photoperiod- and temperature-controlled, ventilated compartments.…”

Section: Methodsmentioning

confidence: 99%

“…During experiments, home cage or running wheel activity was recorded continuously except during the two days when blood samples were collected. Phase shifts in the circadian activity rhythms were determined using the linear regression method and Clocklab software, as described previously (Legan et al, 2009). …”

Section: Methodsmentioning

confidence: 99%

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Effect of arousing stimuli on circulating corticosterone and the circadian rhythms of luteinizing hormone (LH) surges and locomotor activity in estradiol-treated ovariectomized (ovx+EB) Syrian hamsters

Legan

Peng

Yun

et al. 2015

Hormones and Behavior

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In most proestrous hamsters, novel wheel exposure phase advances activity rhythms and blocks the preovulatory LH surge, which occurs 2 h earlier the next day. Because wheel immobilization does not prevent these effects we hypothesized that arousal alone blocks and phase advances the LH surge. Ovariectomized (ovx) hamsters received a jugular vein cannula and estradiol benzoate (EB) or vehicle was injected sc. The next day (Day 1), at zeitgeber time (ZT) 4-5 (ZT 12=lights off), after obtaining a blood sample, each hamster was exposed to constant darkness (DD), and either remained in her home cage or was transferred to a new cage and exposed to a running wheel or a 2-h arousal paradigm. Blood samples were obtained in dim red light and activity was recorded hourly until ~ZT 10-11 on Days 1 and 2. For the next 1-2 weeks, activity was monitored in DD. Plasma LH and corticosterone were assessed by RIA. Novel wheel exposure or arousal at ZT 4 greatly attenuated the Day 1 LH surge in ovx+EB hamsters, and phase advanced the Day 2 LH surge by about 2 hours. In proestrous hamsters, novel wheel exposure led to a prolonged (>2 h) increase in corticosterone levels only when LH surges were blocked. Phase advances in activity rhythms were enhanced by estradiol and arousal. The results suggest that estradiol modulates the effectiveness of non-photic stimuli. The role of the increased activity of the hypothalamic-pituitary-adrenal axis associated with novel wheel-induced attenuation of LH surges in ovx+EB hamsters remains to be determined.

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“…Ayrıca GABA reseptörleri, suprakiazmatik çekirdek (SKÇ) ile bağlantısının olduğu beyinin birçok alanında saptanmış-tır (24). Muscimol, triazolam ve fenobarbital gibi GABAerjik agonistlerin, SKÇ'teki per1 ve per2 gibi CLOCK genlerin ekspresyonunu değiştirerek sirkadiyan ritmin faz kaymasını uyardığı gösterilmiştir (25,26). Cheeseman ve ark.…”

Section: Grupunclassified

Effect of Day and Night Desflurane Anaesthesia on Melatonin Levels in Rats

Özer¹,

Öçmen²,

Akan³

et al. 2016

Turk J Anaesth Reanim

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Amaç: Bu çalışmanın amacı ratlarda gece-gündüz desfluran uygulamasının melatonin düzeyi üzerine etkisinin araştırılmasıdır.Yöntemler: Çalışmaya 15 günlük 24 adet rat alındı ve rastgele 4 gruba ayrıldı. Ratlara bahar döneminde 19:00-01:00 (gece grubu) ve 07:00-13:00 (gündüz grubu) saatleri arasında 6 L dk -1 akım hızında %100 oksijen içinde %5,7 desfluran uygulandı. Kontrol gruplarına ise aynı zaman süresince 6 L dk -1 akım hızında oksijen uygulandı. Altı saatlik sürenin sonunda kan örnekleri alındıktan sonra ratlar sakrifiye edildi. Alınan kanlar santrifüj edildi ve elde edilen plazmalarda melatonin düzeyleri radioimmünoassay yön-temi ile ölçüldü.Bulgular: Tüm gruplar karşılaştırıldığında gruplar arasında anlamlı fark saptandı (p=0,007). Gündüz kontrol ve gece kontrol grupları karşılaştırıldığında gruplar arasında anlamlı fark olduğu görüldü (p=0,042). Ayrıca gündüz kontrol ve gece desfluran grupları arasında anlamlı fark saptandı (p=0,024). Diğer gruplar arasında anlamlı fark saptanmadı. Sonuç:On beş günlük ratlarda yaptığımız bu çalışma ile altı saatlik %5,7 konsantrasyondaki desfluranın gece veya gündüz uygulanmasının melatonin düzeyini etkilemediğini saptadık. Anahtar kelimeler: Melatonin, desfluran, ratObjective: The aim of this study is to investigate the effect of day and night administration of desflurane anaesthesia on melatonin levels in rats.Methods: Twenty-four 15-day-old rats were included in the study and were divided into four groups. The rats were anaesthetised between 19:00-01:00 (night group) and 07:00-13:00 (day group) with 5.7% desflurane concentration in 6 L min −1 100% oxygen. 6 L min −1 oxygen was administered to the control groups. At the end of 6 h of anaesthesia, blood samples were taken, and rats were sacrificed. Blood samples were centrifuged and melatonin levels from plasma samples were measured with radioimmunoassay.Results: There was a statistically significant difference between the groups (p=0.007). Between group day control and group night control there was a statistically significant difference (p=0.042). Further, there was a significant difference between group day control and night desflurane (p=0.024). We could not find any difference between other groups. Conclusion:This study showed that 6 hours of 5.7% desflurane anaesthesia during day and night hours did not significantly change melatonin levels.

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Phenobarbital blockade of the preovulatory luteinizing hormone surge: association with phase-advanced circadian clock and altered suprachiasmatic nucleus Period1 gene expression

Cited by 15 publications

References 63 publications

2,2,2-Tribromoethanol Phase-Shifts the Circadian Rhythm of the Liver Clock in Per2::Luciferase Knockin Mice: Lack of Dependence on Anesthetic Activity

2,2,2-Tribromoethanol Phase-Shifts the Circadian Rhythm of the Liver Clock in Per2::Luciferase Knockin Mice: Lack of Dependence on Anesthetic Activity

Effect of arousing stimuli on circulating corticosterone and the circadian rhythms of luteinizing hormone (LH) surges and locomotor activity in estradiol-treated ovariectomized (ovx+EB) Syrian hamsters

Effect of Day and Night Desflurane Anaesthesia on Melatonin Levels in Rats

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