Pheno2GRN

Abstract

While efforts have been made to both retrieve genes associated with a phenotype, and model gene regulatory networks (GRNs), no such progress has been made regarding the creation of GRNs from phenotype keywords and reverse engineered large-scale gene expression datasets, such as microarray data. In this work, we describe a Java web application called Pheno2GRN (available at http://jacksons.usd.edu/Pheno2GRN), which allows users to select a phenotype keyword and be presented with a visualization of the GRN associated with the phenotype. The GRN created from the phenotype can be compared with one reverse engineered from microarray datasets. Pheno2GRN also incorporates analytic tools for modeling phenotype gene intersections and gathers all results in a useful, downloadable reporting section.