Phenformin attenuates the oxidative-nitrosative stress in the liver of rats under long-term ethanol administration
A. Mykytenko,
O. Akimov,
G. Yeroshenko
et al.
Abstract:Modulation of the AMP-activated protein kinase (AMPK) pathway activity is considered to be a promising option in the development of approaches to chronic alcoholic hepatitis treatment. Phenformin, which is a biguanide, has been reported to increase AMPK activity. The aim of this work was to estimate the effect of phenformin as AMPK activator on the development of oxidative-nitrosative stress in the liver of rats under conditions of long-term ethanol administration. The experiments were performed on 24 male Wi… Show more
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