Phenelzine and Dexamphetamine in Depressive Illness

Hare, E. H.; Dominian, J.; Sharpe, Louise

doi:10.1136/bmj.1.5270.9

Cited by 44 publications

(7 citation statements)

References 4 publications

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“…The few controlled trials available cast doubt as to whether the amphetamines are more effective than placebo (Hare, Dominian, and Sharpe 1962;General Practitioner Research Group 1964). Among Veterans AdminiBtration (V .A.)…”

Section: Amphetamines and Related Psychomotor Stimulantsmentioning

confidence: 99%

Brain Chemistry and Mental Disease

Ho¹,

McIsaac²

1971

Advances in Behavioral Biology

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PREFACEThis volume contains the proceedings of the fourth international symposium held in November 1970 at the Texas Research Institute of Mental Sciences in Houston. Leading psychiatrists, biochemists, and pharmacologists from the United States and Great Britain presented new material and reviewed current concepts concerning schizophrenia and the affective disorders, with particular reference to the neurochemical basis of the etiology and chemotherapy of these diseases.Although the multiple mechanisms of mental disease are still not fully understood, substantial progress has definitely been made. The greatest contribution has come through the development of new therapeutic agents that not only provide invaluable help to the mentally ill but serve as chemical tools for studying the biological mechanisms associated with the disease state. Studies concerning the proposed catecholamine and indolealkylamine hypotheses for affective disorders and the possible formation of endogenous. toxins in schizophrenia have stimulated significant new research.This book presents new studies of schizophrenia and the affective disorders in one volume. It is our hope that it represents an effective integration of basic biochemical and pharmacological research with current clinical findings and that it will increase understanding of the etiology of mental disease and provide an impetus for the development of more effective therapeutic agents.We thank Drs.

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Section: Amphetamines and Related Psychomotor Stimulantsmentioning

confidence: 99%

Brain Chemistry and Mental Disease

Ho¹,

McIsaac²

1971

Advances in Behavioral Biology

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“…74 Another study compared phenelzine with dextroamphetamine and placebo; no differences were found in regard to the symptoms of depression, but anxiety and agitation were better relieved by phenelzine. 39 A comparison between imipramine, isocarboxazide, a dextroamphetamine-amobarbital combination, and placebo indicated that imipramine was slightly but significantly better than the other treatments. This study emphasized that all treatments showed considerable improvement over baseline, indicating the need to control for spontaneous remission, and that improvement would appear within three weeks in most patients who were going to respond to a drug.…”

Section: Antidepressantsmentioning

confidence: 99%

Clinical use of psychotherapeutic drugs: Current status

Hollister

1969

Clin Pharma and Therapeutics

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The clinical efficacy of present psychotherapeutic drugs varies among the various types. Antianxiety agents are most controversial, as a great many confounding, metapharmacological variables influence the results obtained. The use of such drugs in traditional doses and dosage schedules also may not employ them to best advantage. Antidepressants must increasingly be considered in relation to the clinical type of depressive reaction being treated. Tricyclic drugs are clearly indicated for retarded or endogenous depressions; in exceptional cases, monoamine oxidase inhibitors may merit a trial in such patients. Depressions characterized by much attendant anxiety may respond better to phenothiazines or to antianxiety agents. Consequently, the scope of “antidepressants” may be larger than simply one or two drug classes. Antipsychotics are clearly effective. A large number of peer drugs are available, although it seems clear that, for reasons still to be elucidated, individual patients may respond better to one than to another. Drug therapy of other types of psychiatric disorder, such as mental retardation, childhood and adolescent behavior disorders, alcoholism, and psychoses associated with old age, is of limited value. Lithium salts may represent a significant advance in the management and prevention of manic attacks.

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“…The sampIe path drawn in Fig. 3 has been taken from the publication of a trial by Hare, Dominian, and Sharpe, 9 in which the effects of phenelzine and dexamphetamine in depressive illness were compared.…”

Section: Zone Of Indifferencementioning

confidence: 99%