Phenelzine and Amitriptyline in the Treatment of Depression

Ravaris, C. Lewis; Robinppson, Donald S.; Ives, John O.; Nies, Alexander; Bartlett, Diantha

doi:10.1001/archpsyc.1980.01780220113013

Cited by 113 publications

(18 citation statements)

References 23 publications

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“…Panic disorder without agoraphobia was not associated with this condition. Although most research assessing the predictive value of comorbid anxiety for MAOI response rates in patients with atypical features has focused on the presence of comorbid panic attacks, 19,20,27,29,30,42,44,46,47 our results suggest that the phobic element may be more relevant.…”

Section: Commentmentioning

confidence: 65%

“…Consistent with other reports, 11,14,22,32,42,43 we did not find any evidence to suggest that mood reactivity is associated with the atypical B symptoms. In some antidepressant trials, the presence of mood reactivity has been shown to predict a preferential MAOI response, 33,44 whereas other studies have found that it is not predictive 34 or that mood unreactivity predicts a superior MAOI response. 19,22,45 Of the remaining atypical symptoms, correlation analyses revealed significant but modest associations.…”

Section: Commentmentioning

confidence: 97%

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Partial Validation of the Atypical Features Subtype of Major Depressive Disorder

Posternak¹,

Zimmerman²

2002

Arch Gen Psychiatry

102

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Background: Symptoms of the atypical features subtype of major depressive disorder include mood reactivity, hypersomnia, hyperphagia, leaden paralysis, and rejection sensitivity. This subtype was introduced into the mood disorders section of the DSM-IV following a series of antidepressant trials showing that such patients responded preferentially to monoamine oxidase inhibitors. Studies aimed at validating the atypical features subtype have yielded inconsistent results. Our study sought to reevaluate the validity of atypical depression by examining the demographic and clinical features of a large cohort of depressed patients who met DSM-IV criteria for atypical features.

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Section: Commentmentioning

confidence: 65%

Section: Commentmentioning

confidence: 97%

Partial Validation of the Atypical Features Subtype of Major Depressive Disorder

Posternak¹,

Zimmerman²

2002

Arch Gen Psychiatry

102

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“…There is on the side of the tricyclics a considerable volume of studies showing that they are superior to placebo in outpatient neurotic depressives and increasing evidence that they are ineffective in severe deluded depressives (Paykel, 1979). Ravaris et al (1980) recently found only weak differences between amitriptyline and phenelzine in symptom effects in anxious depressives. There is evidence that tricyclics are superior to placebo in agoraphobics (Sheehan et al, 1980;Zitrin et al, 1980), and in obsessional neuroses (Marks et al, 1980).…”

Section: Atypical Depressionmentioning

confidence: 98%

The classification of depression.

Paykel¹

1983

Brit J Clinical Pharma

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“…nonselective. irre versible MAOIs such as phenelzine, isocarboxazid, and tranylcypromine) appear to be superior to tricyclic antide pressants in the treatment of atypical depression which is characterized by: mood reactivity, hyperphagia, hyper somnia, extreme fatigue, and oversensitivity to rejection [93][94][95][96], With the careful monitoring of dietary intake, the standard MAOIs are a safe and effective treatment of depression in the geriatric population. Georgotas ct al.…”

Section: Standard Maoismentioning

confidence: 99%

Depression in the Elderly

Rosenberg

Wright

Gershon

1992

Dement Geriatr Cogn Disord

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This paper examines the clinical presentation of, the biochemical abnormalities associated with, and the treatment of depressive disorders in late life. A comparison of geriatric depression (late-onset, first-episode depression) will be made to depression as it presents in childhood and middle age. Childhood onset depression is now accepted as a valid diagnostic/clinical entity. However, there is no conclusive evidence to date that pharmacologic intervention is effective in the treatment of childhood onset depressive disorder. On the other hand, major depression occurring in middle age has been shown to be quite responsive to pharmacologic interventions. Although the precise mechanism of pharmacologic intervention is unknown, certain biochemical abnormalities have been associated with middle-age onset of depression. We will discuss the similarities and differences of depression in the elderly to depression in both middle age and childhood. It is often difficult to diagnose a depressive disorder within the geriatric population. In addition to a primary depression, elderly individuals are susceptible to other syndromes which may present in a fashion similar to depression. These include depressive reactions associated with dementia and demoralization in the elderly. In addition, depression, especially in the elderly, may masquerade as other clinical entities. Following the discussion of the diagnostic difficulties associated with depression in the elderly, we will discuss potential treatment modalities for late-onset, first-episode depression. This will include an examination of common antidepressant treatments, such as tricyclic antidepressants and monoamine oxidase inhibitors, as well as other less frequently used and experimental treatment modalities.

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Phenelzine and Amitriptyline in the Treatment of Depression

Cited by 113 publications

References 23 publications

Partial Validation of the Atypical Features Subtype of Major Depressive Disorder

Partial Validation of the Atypical Features Subtype of Major Depressive Disorder

The classification of depression.

Depression in the Elderly

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