Phencyclidine use during pregnancy

Golden, Nancy L.; Kuhnert, Betty R.; Sokol, Robert J.; Martier, Susan S.; Bagby, B.S.

doi:10.1016/s0002-9378(84)80063-0

Cited by 23 publications

(8 citation statements)

References 8 publications

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“…Most patients lost to follow-up were lost due to delivery at another hospital, delivery at times when examinations could not be obtained or refusal participate. The demographic characteristics of this population has been described in depth [4] and previous analysis indicated that there were no significant demographic differences between the patients studied and those lost to followup. Table III shows that study and control groups differed significantly only in the mean number of drugs used.…”

Section: Resultsmentioning

confidence: 92%

“…This was probably due to infrequent urine testing [4]. Therefore, the frequency of phencyclidine use (which exceeds 15% in some populations [9]) would almost certainly be underestimated and many users would have been missed if only the confirmed users had been studied.…”

Section: Discussionmentioning

confidence: 99%

“…Trained screeners took substance abuse histories [4] and administered Michigan Alcoholism Screening Tests [10].…”

Section: Methodsmentioning

confidence: 99%

“…gave a verbal history of phencyclidine use but only 0.8 percent could be confirmed as current users by maternal urine screening [4], The purpose of the present study was to describe the physical characteristics, neurologic findings, behavior, and neonatal clinical course of the infants of these women, and to compare them with a group of matched control infants.…”

Section: Introductionmentioning

confidence: 96%

“…Given the reported frequency of phencyclidine use, the fact that phencyclidine crosses the placenta, and the possibility that intrauterine exposure to phencyclidine may be harmful to the fetus, we undertook a large prospective study to describe the extent of phencyclidine use during pregnancy and the characteristics of the user population [4]. gave a verbal history of phencyclidine use but only 0.8 percent could be confirmed as current users by maternal urine screening [4], The purpose of the present study was to describe the physical characteristics, neurologic findings, behavior, and neonatal clinical course of the infants of these women, and to compare them with a group of matched control infants.…”

Section: Introductionmentioning

confidence: 99%

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Neonatal manifestations of maternal phencyclidine exposure

Golden

Kuhnert²,

Sokol³

et al. 1987

Journal of Perinatal Medicine

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The purpose of this study was to determine the effects of maternal phencyclidine use on the fetus. Ninety-four neonates with maternal phencyclidine exposure were compared with 94 controls. Maternal phencyclidine use was assessed by questionnaire and repeated urine testing. Mothers of study and control patients were matched for demographic characteristics. Infants were assessed between 24-72 hours postnatally by a single examiner blind to the maternal history. The results showed that study infants had a mean of 5.02 +/- 2.93 abnormalities while controls had a mean of 4.13 +/- 2.65 abnormalities (p less than 0.01). Furthermore, study infants were more likely than controls to have poor attention, hypertonia, and depressed neonatal reflexes (p less than 0.05). The contribution of seven drug classes to the total number of abnormalities was assessed using stepwise multiple regression. Only phencyclidine accounted for a significant proportion of the variance (f = 4.38; p less than 0.05). The results of this study suggest that maternal phencyclidine use may lead to abnormal neonatal neurologic findings and behavior.

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Section: Resultsmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

“…Trained screeners took substance abuse histories [4] and administered Michigan Alcoholism Screening Tests [10].…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%