Phencyclidine-induced abnormal behaviors in rats as measured by the hole board apparatus

Abstract

These results suggest that PCP-induced decrease in exploratory behavior are attributable to antagonism of NMDA receptors and may not involve dopaminergic transmission via D2 receptors.

Sub-chronic psychotomimetic phencyclidine induces deficits in reversal learning and alterations in parvalbumin-immunoreactive expression in the rat

“…A single dose of PCP has been shown to intensify the symptoms of schizophrenia in patients, to produce hallucinations and to reduce cognitive ability (Krystal et al, 1994;Steinpreis, 1996;Jentsch and Roth, 1999). In addition, acute PCP administration in animals has been shown to produce deficits in pre-pulse inhibition (PPI) of the startle response, a measure of sensorimotor gating deficits (Ballmaier et al, 2001; for review see Geyer et al, 2001), to increase locomotor activity (Yamaguchi et al, 1986;Redmond et al, 1999;Morita et al, 2000) and to produce cognitive deficits of particular relevance to schizophrenia (AbdulMonim et al, 2003a;Idris et al, 2005).…”

Administration of eliprodil during ethanol withdrawal in the neonatal rat attenuates ethanol-induced learning deficits

“…However, MK-801 is a potent antagonist that acts at the phencyclidine (PCP) site within the NMDA-receptor-gated channel and can produce psychotomimetic and amnestic side effects (Sanger 1992;Verma and Moghaddam 1996;Morito et al 2000;Svensson 2000;Wedzony et al 2000) as well as neurotoxicity (Ikonomidou et al 1999). In fact, if MK-801 is given at the same time as ethanol treatment during development, mortality rates are increased and behavioral alterations are exacerbated (Thomas et al 2001).…”

NEUROPHARMACOLOGICAL ASSESSMENT OF AN AQUEOUS BARK EXTRACT OF <i>ANTIARIS TOXICARIA</i> (PERS.) LESCH. (MORACEAE) IN RODENTS

“…Substances with marked psychostimulant properties are expected to increase locomotor activity (Riviere et al, 1999;Kafkafi et al, 2001;Gentry et al, 2004). But can cause a decrease due to animals rotating rapidly in a small space or showing stereotyped behaviours (Morita et al, 2000;Quinn et al, 2003). The increase in locomotor activity at higher doses may be due to some increased exploratory behaviour that may be evident with anxiolytic compounds such as these benzodiazepines (Turski et al, 1982).…”