Phenanthroline and Schiff Base associated Cu(II)-coordinated compounds containing N, O as donor atoms for potent anticancer activity

Richa,; Kumar, Vinod; Kataria, Ramesh

doi:10.1016/j.jinorgbio.2023.112440

Cited by 7 publications

(2 citation statements)

References 142 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Being one of the essential metals, copper has widespread applications not only in redox chemistry but also in the field of chemotherapeutic drug discovery. 5–10 The structural variation in the metal center provides the required steric properties, and the well-established coordination chemistry has provided thorough insights into its potential use as a promising replacement. Furthermore, the antibacterial, antifungal, antiviral, cytotoxic and DNA binding/cleaving activities have been studied.…”

Section: Introductionmentioning

confidence: 99%

Mononuclear copper(ii) complexes with polypyridyl ligands: synthesis, characterization, DNA interactions/cleavages and in vitro cytotoxicity towards human cancer cells

Muley,

Kumbhakar,

Raut

et al. 2024

Dalton Trans.

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Mononuclear copper(ii) complexes with polypyridyl ligands: synthesis, characterization, DNA interactions/cleavages and in vitro cytotoxicity towards human cancer cells

Muley,

Kumbhakar,

Raut

et al. 2024

Dalton Trans.

View full text Add to dashboard Cite

show abstract

“…Schiff bases are formed when an aldehyde or ketone reacts with a primary amine When an aldehyde or ketone is combined with a primary amine [ 1 , 2 ], resulting in a compound with an azomethine group containing HC = N bonds [ 3 ]. These ligands are essential in coordination chemistry for creating stable complexes with metal ions, first discovered by Hugo Schiff in 1864 [ 4 , 5 ], Schiff base ligands play a crucial role [ 6 , 7 ] based on their physicochemical characteristics [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

Olive leaf extract-assisted green synthesis of cd nano complex: A combined experimental and theoretical study

Alshammari,

H. Taha,

Almutlq

et al. 2024

PLoS ONE

View full text Add to dashboard Cite

Research in the synthesis of Schiff base ligands and their metal complexes using olive leaf extracts as a green reducing agent is an exciting area of study. In this research, a Schiff base ligand is created by combining 1-hydroxy-2-naphthaldehyde and amino-N-(4,6-dimethylpyrimidin-2-yl)-4-benzenesulfonamide. The synthetic Schiff base is then utilized for the production of a Cd(II) nano complex for the first time with olive leaf extracts serving as the green reducing agent. The extract is obtained by harvesting, drying, and grinding the olive leaves. Various analytical techniques, including 1H NMR, 13C NMR spectroscopy, scanning electron microscope (SEM), and conductivity studies, are employed to analyze the Schiff base and its Cd(II) complex. Quantum chemical calculations are also conducted to explore the different conformers of the Cd(II) complex and their stabilities, shedding light on the synthesis pathways of the Schiff base ligand and Cd(II) complex. Extensive DFT-based geometry optimizations and frequency calculations are carried out for 1-hydroxy-2-naphthaldehyde,amino-N-(4,6-dimethylpyrimidin-2-yl)-4-benzenesulfonamide, the Schiff base ligand, and the corresponding Cd(II) complex. Experimental and theoretical analyses confirm the presence of the azomethine (-HC = N-) group in the Schiff base and validate the formation of the Cd(II) complex in a 2:1 metal-to-ligand ratio through physicochemical characterization methods, highlighting the nanoscale structure of the complex. Combining thorough physicochemical investigations with molecular modeling simulations and the sustainable synthesis of metal complexes, valuable insights into their properties and potential applications in catalysis and drug delivery are obtained.

show abstract

Structural elucidation of a new binuclear copper(II)/phenanthroline/2-(2,4-dihydroxybenzoyl)benzoate complex by synchrotron radiation, DNA interaction and cytotoxicity against tumor cells

Montilla-Suárez,

Loures dos Santos,

de Araújo

et al. 2024

Inorganic Chemistry Communications

View full text Add to dashboard Cite

Phenanthroline and Schiff Base associated Cu(II)-coordinated compounds containing N, O as donor atoms for potent anticancer activity

Cited by 7 publications

References 142 publications

Mononuclear copper(ii) complexes with polypyridyl ligands: synthesis, characterization, DNA interactions/cleavages and in vitro cytotoxicity towards human cancer cells

Mononuclear copper(ii) complexes with polypyridyl ligands: synthesis, characterization, DNA interactions/cleavages and in vitro cytotoxicity towards human cancer cells

Olive leaf extract-assisted green synthesis of cd nano complex: A combined experimental and theoretical study

Structural elucidation of a new binuclear copper(II)/phenanthroline/2-(2,4-dihydroxybenzoyl)benzoate complex by synchrotron radiation, DNA interaction and cytotoxicity against tumor cells

Contact Info

Product

Resources

About