pHEMA@AGMNA-1: A novel material for the development of antibacterial contact lens

Rossos, Andreas K.; Banti, Christina N.; Kalampounias, Angelos G.; Papachristodoulou, C.; Kordatos, Konstantinos; Zoumpoulakis, Panagiotis; Mavromoustakos, Thomas; Kourkoumelis, Nikolaos; Hadjikakou, Sotiris K.

doi:10.1016/j.msec.2020.110770

Cited by 28 publications

(54 citation statements)

References 31 publications

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“…The pHEMA, pHEMA@ORLE_2, and pHEMA@AgNPs(ORLE)_2 discs of 10-mm diameter were cut, cleaned from monomers, and stored either in sterilized NaCl 0.9% w/w solution or they were dried at 50 • C (Figure S1). [7], although the ideal hydrogels should have a refractive index value matching the range of 1.372-1.381 [3]. However, the fabricated hydrogel is highly transparent, with refractive indexes ranging from 1.42 to 1.45 in the spectra range from 400 to 800 nm [15,16].…”

Section: General Aspectsmentioning

confidence: 99%

“…This initiates the research for novel material's' development, which exhibits the benefits of typical contact lenses without the peril for severe bacterial infections. The dispersion of antimicrobial agents leads to loading of antibacterial properties in the polymeric material [6,7]. Silver(I) ions have been pursued as additives to contact lenses for their antimicrobial efficacy [8].…”

Section: Introductionmentioning

confidence: 99%

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Silver Nanoparticles from Oregano Leaves’ Extracts as Antimicrobial Components for Non-Infected Hydrogel Contact Lenses

Meretoudi

Banti

Raptis

et al. 2021

IJMS

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The oregano leaves’ extract (ORLE) was used for the formation of silver nanoparticles (AgNPs(ORLE)). ORLE and AgNPs(ORLE) (2 mg/mL) were dispersed in polymer hydrogels to give the pHEMA@ORLE_2 and pHEMA@AgNPs(ORLE)_2 using hydroxyethyl–methacrylate (HEMA). The materials were characterized by X-ray fluorescence (XRF) spectroscopy, X-ray powder diffraction analysis (XRPD), thermogravimetric differential thermal analysis (TG-DTA), derivative thermogravimetry/differential scanning calorimetry (DTG/DSC), ultraviolet (UV-Vis), and attenuated total reflection mode (ATR-FTIR) spectroscopies in solid state and UV–Vis in solution. The crystallite size value, analyzed with XRPD, was determined at 20 nm. The antimicrobial activity of the materials was investigated against Gram-negative bacterial strains Pseudomonas aeruginosa (P. aeruginosa) and Escherichia coli (E. coli). The Gram-positive ones of the genus of Staphylococcus epidermidis (S. epidermidis) and Staphylococcus aureus (S. aureus) are known to be involved in microbial keratitis by the means of inhibitory zone (IZ), minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC). The IZs, which developed upon incubation of P. aeruginosa, E. coli, S. epidermidis, and S. aureus with paper discs soaked in 2 mg/mL of AgNPs(ORLE), were 11.7 ± 0.7, 13.5 ± 1.9, 12.7 ± 1.7, and 14.3 ± 1.7 mm. When the same dose of ORLE was administrated, the IZs were 10.2 ± 0.7, 9.2 ± 0.5, 9.0 ± 0.0, and 9.0 ± 0.0 mm. The percent of bacterial viability when they were incubated over the polymeric hydrogel discs of pHEMA@AgNPs(ORLE)_2 was interestingly low (66.5, 88.3, 77.7, and 59.6%, respectively, against of P. aeruginosa, E. coli, S. epidermidis, and S. aureus) and those of pHEMA@ORLE_2 were 89.3, 88.1, 92.8, and 84.6%, respectively. Consequently, pHEMA@AgNPs(ORLE)_2 could be an efficient candidate toward the development of non-infectious contact lenses.

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Section: General Aspectsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Silver Nanoparticles from Oregano Leaves’ Extracts as Antimicrobial Components for Non-Infected Hydrogel Contact Lenses

Meretoudi

Banti

Raptis

et al. 2021

IJMS

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“…S. aureus is also capable of forming a biofilm on the cornea (Figure 1) and on contact lenses [30,31]. A biofilm consists of a secreted extracellular polymeric substance which protects bacterial populations from host defences.…”

Section: Biofilm Formation and Contact Lensesmentioning

confidence: 99%

“…Since improper contact lens hygiene remains a significant risk factor for bacterial keratitis [32], studies have focused on current disinfecting contact lens solutions [70] and novel options. One such example is the metal organic framework AGMNA, which includes silver (a known antimicrobial agent) and an anti-metabolite, 2-thio-nicotinic acid (H2MNA) [31]. This compound has been investigated as a substitute for the more widely used component polyhexanide, for which there are concerns due to its suspected carcinogenic effects [71].…”

Section: Novel Therapeuticsmentioning

confidence: 99%

“…In addition to disinfecting solutions, antimicrobial drugs and compounds have been incorporated into the design of the contact lens themselves. AGMNA has proven to be a good candidate for the design of a contact lens with an inherent antimicrobial effect against S. aureus, P. aeruginosa and S. epidermidis [31]. Contact lenses have also been modified to slowly release antimicrobials onto the cornea, such as nitric oxide [73] and ciprofloxacin [74] over 8-16 h. These types of lenses have been proven to be effective against S. aureus and P. aeruginosa in ex vivo rabbit corneal models [75].…”

Section: Novel Therapeuticsmentioning

confidence: 99%

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Staphylococcus aureus Keratitis: Incidence, Pathophysiology, Risk Factors and Novel Strategies for Treatment

Lee

Somerville

Kaye

et al. 2021

JCM

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Bacterial keratitis is a devastating condition that can rapidly progress to serious complications if not treated promptly. Certain causative microorganisms such as Staphylococcus aureus and Pseudomonas aeruginosa are notorious for their resistance to antibiotics. Resistant bacterial keratitis results in poorer outcomes such as scarring and the need for surgical intervention. Thorough understanding of the causative pathogen and its virulence factors is vital for the discovery of novel treatments to avoid further antibiotic resistance. While much has been previously reported on P. aeruginosa, S. aureus has been less extensively studied. This review aims to give a brief overview of S. aureus epidemiology, pathophysiology and clinical characteristics as well as summarise the current evidence for potential novel therapies.

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Lab‐on‐a‐Contact Lens: Recent Advances and Future Opportunities in Diagnostics and Therapeutics

Zhu

et al. 2022

Advanced Materials

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The eye is one of the most complex organs in the human body, containing rich and critical physiological information (e.g., intraocular pressure, corneal temperature, and pH) as well as a library of metabolite biomarkers (e.g., glucose, proteins, and specific ions). Smart contact lenses (SCLs) can serve as a wearable intelligent ocular prosthetic device capable of noninvasive and continuous monitoring of various essential physical/biochemical parameters and drug loading/delivery for the treatment of ocular diseases. Advances in SCL technologies and the growing public interest in personalized health are accelerating SCL research more than ever before. Here, we discussed the current status and potential of SCL development through This article is protected by copyright. All rights reserved. a comprehensive review from fabrication to applications to commercialization. First, we discuss the material, fabrication, and platform designs of the SCLs for the diagnostic and therapeutic applications. Then, we review the latest advances in diagnostic and therapeutic SCLs for clinical translation. Later, we summarize the established techniques for wearable power transfer and wireless data transmission applied to current SCL devices. We also provide an outlook, future opportunities, and challenges for developing next-generation SCL devices. With the rise in interest of SCL development, this comprehensive and essential review can serve as a new paradigm for the SCL devices.

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pHEMA@AGMNA-1: A novel material for the development of antibacterial contact lens

Cited by 28 publications

References 31 publications

Silver Nanoparticles from Oregano Leaves’ Extracts as Antimicrobial Components for Non-Infected Hydrogel Contact Lenses

Silver Nanoparticles from Oregano Leaves’ Extracts as Antimicrobial Components for Non-Infected Hydrogel Contact Lenses

Staphylococcus aureus Keratitis: Incidence, Pathophysiology, Risk Factors and Novel Strategies for Treatment

Lab‐on‐a‐Contact Lens: Recent Advances and Future Opportunities in Diagnostics and Therapeutics

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