Phasic capillary pressure determined by arterial occlusion in intact dog lung lobes

Yamada, Yosuke; Suzukawa, Masayuki; Chinzei, Mieko; Chinzei, Tsuneo; Kawahara, Nobutaka; Suwa, Kuniaki; Numata, K

doi:10.1152/jappl.1989.67.6.2205

Cited by 17 publications

(10 citation statements)

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“…The same was true for 34 out of 37 postocclusion arterial pressure profiles. The later observation agrees with those of DAWSON et al [1] and YAMADA et al [16]. The fit of the arterial and venous occlusion pressure-time profiles by the sum of two exponentials, rather then by an instantaneous drop followed by a single exponential, suggests that compliant rather than resistive components predominate near the arterial and venous occlusion sites [17].…”

Section: Estimations Of Capillary Pressure From the Venous And Arterisupporting

confidence: 87%

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Capillary pressure estimates from arterial and venous occlusion in intact dog lung

Corboz¹,

Sanou²,

Grimbert³

1995

Eur Respir J

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C Ca ap pi il ll la ar ry y p pr re es ss su ur re e e es st ti im ma at te es s f fr ro om m a ar rt te er ri ia al l a an nd d v ve en no ou us s o oc cc cl lu us si io on n i in n i in nt ta ac ct t d do og g l lu un ng g ABSTRACT: We performed pulmonary venous occlusions in order to check the validity of the pulmonary capillary pressure measurements obtained using pulmonary arterial occlusion in the intact animal.The venous and arterial postocclusion pressure profiles were recorded using balloon catheters introduced, respectively, into a left lower lobe vein and into a right pulmonary artery in the anaesthetized open-chest dog.The pressure profiles were fitted by a biexponential function with an early exponential and a late exponential presenting, respectively, a short and a long time constant. We used the zero-time extrapolation of the late slow exponential to obtain an arterial (Pc,ao) and a venous (Pc,vo) estimate of the pulmonary capillary pressure. Each P c,ao and P c,vo made it possible to calculate a fractional arterial or venous pressure gradient when referenced to the arteriovenous pressure gradient measured during the occlusion process. In nine dogs, when referenced to the whole lung, the arterial, middle and venous fractional pressure gradients were 37±11, 10±6, and 53±12%, respectively.As the middle fractional pressure gradient is low, we conclude that pulmonary capillary pressure estimates from arterial occlusion are close to the venous occlusion estimates of capillary pressure in the intact dog lung.

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Section: Estimations Of Capillary Pressure From the Venous And Arterisupporting

confidence: 87%

“…One factor is the sluggishness of the occlusion process when it is performed using an intravascular balloon [2,22] instead of using an external clamp [16]. This may delay the time of complete occlusion and shorten the backextrapolation of the slow exponential segment, resulting in a lower Pc,ao and a higher Pc,vo.…”

Section: Middle Pressure Gradientmentioning

confidence: 99%

Capillary pressure estimates from arterial and venous occlusion in intact dog lung

Corboz¹,

Sanou²,

Grimbert³

1995

Eur Respir J

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“…Since both the arterial and venous segments of the pulmonary circulation can be characterised by resistive and compliant properties, BACONNIER et al [7] formalised a three-compartment C-R-C-R-C model, and proposed an exact solution to compute Pc from the bi-exponential fitting of the Ppa decay curve. As there is a phasic variation of Pcc within the cardiac cycle [17], Pc may be better normalised to mean Ppa [10]. In the present study, this method of calculation led to lower Pc values than previously found using a mono-exponential fitting in PPH patients [3,18].…”

Section: Computing Of Pulmonary Capillary Pressurementioning

confidence: 42%

Single arterial occlusion to locate resistance in patients with pulmonary hypertension

Fesler

Pagnamenta²,

Vachiéry³

et al. 2003

Eur Respir J

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The purpose of this study was to determine the site of increased resistance using the arterial occlusion technique in patients with severe pulmonary hypertension.Pulmonary vascular resistance was partitioned in arterial and venous components based on double exponential fitting analysis of the pulmonary artery pressure decay curve: after balloon occlusion in 36 patients with pulmonary arterial hypertension (PAH); at baseline and during the inhalation of 20 parts per million of nitric oxide (NO); in four patients with chronic thromboembolic pulmonary hypertension; and in two patients with pulmonary veno-occlusive disease.In the patients with PAH, at baseline, mean pulmonary artery pressure was 56¡2 mmHg (mean¡SE), with an arterial component of resistance of 63¡1%. Inhaled NO did not change the partition of resistance. The arterial component of resistance amounted on average to 42% and 77% in the patients with veno-occlusive disease and the patients with thromboembolic pulmonary hypertension, respectively. However, the partitioning of resistance did not discriminate between these three diagnostic categories.The occlusion technique may help to locate the predominant site of increased resistance in patients with severe pulmonary hypertension, but does not allow for a satisfactory differential diagnosis on an individual basis.

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“…Thus, following administration of 5HT, pulmonary vascular resistance increases 2–3 times in the isolated dog lung (Hakim et al . 1982, Hofman & Ehrhart 1987), although in lungs of anaesthetized dogs, it increases only 48% (Yamada et al . 1989) and in awake sheep, it does not increase at all (Brigham & Owen 1975).…”

Section: Discussionmentioning

confidence: 99%

5‐Hydroxytryptamine‐induced microvascular pressure transients in lungs of anaesthetized rabbits

Sen

Glucksberg

Bhattacharya

2001

Acta Physiologica Scandinavica

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We determined lung microvascular pressure transients induced by 5-hydroxytryptamine (5HT), by the micropuncture technique. We mechanically ventilated anaesthetized (halothane 0.8%), open-chested rabbits, in which we recorded pulmonary artery (PA), left atrial (LA) and carotid artery pressures and cardiac output. For 4-min periods of stopped ventilation, we constantly inflated the lung with airway pressure of 7 cmH2O, then micropunctured the lung to determine pressures in arterioles and venules of 20-25 microm diameter. An intravenous bolus infusion of 5HT (100 microg), increased total pulmonary vascular resistance by 59%. Prior to 5HT infusion, the arterial, microvascular and venous segments comprised 30, 50 and 19% of the total pulmonary vascular pressure drop, respectively. However 14 s after 5HT infusion, the PA-arteriole pressure difference (arterial pressure drop) increased 46%, while the venule-LA pressure difference (venous pressure drop) increased >100%. The arteriole-venule pressure difference (microvascular pressure drop) was abolished. The increase in the arterial pressure drop was maintained for 4.8 min, whereas the increased venous pressure drop reverted to baseline in <1 min. We conclude that in the rabbit lung in situ, a 5HT bolus causes sustained arterial constriction and a strong but transient venous constriction.

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Phasic capillary pressure determined by arterial occlusion in intact dog lung lobes

Cited by 17 publications

References 0 publications

Capillary pressure estimates from arterial and venous occlusion in intact dog lung

Capillary pressure estimates from arterial and venous occlusion in intact dog lung

Single arterial occlusion to locate resistance in patients with pulmonary hypertension

5‐Hydroxytryptamine‐induced microvascular pressure transients in lungs of anaesthetized rabbits

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