Phasic and Mean Blood Flow in the Canine Septal Artery and an Estimate of Systolic Resistance in Deep Myocardial Vessels

Eckstein, Richard W.; Moir, Thomas W.; Driscol, Thomas E.

doi:10.1161/01.res.12.2.203

Cited by 30 publications

(7 citation statements)

References 12 publications

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“…The rotameter determinations of this and other studies 14 have shown an average septal arterial flow of 13.6 ml/min (range 10.2 to 24.3 ml), or 83.2 ml/min per 100 g of septum (range 45.5 to 154.0 ml) ; this flow represents an average of 16.0% of total left coronary flow (range 11.4% to 21.1%). Thus, with an average figure of 80% of septal flow draining directly into the right ventricle, it can be derived that an average of 12.8% of the total left coronary flow drains into this chamber via the septal artery.…”

Section: Discussionsupporting

confidence: 57%

Thebesian Drainage of the Septal Artery

Moir

Eckstein

Driscol

1963

Circulation Research

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Direct right ventricular drainage of I 131 serum albumin injected into the septal artery of the normally beating dog heart has been demonstrated. By the application of standard dilution equations to the time-concentration curves recorded in the pulmonary artery, estimates of the magnitude of this Thebesian drainage have been made. Approximately 80% of septal artery outflow has been estimated to drain directly into the right ventricle; this amount comprises about 12.8% of total common left coronary flow and, in part, explains the discrepancy found between common left coronary inflow and coronary sinus outflow. The implications of Thebesian drainage of a branch of the common left coronary artery relative to the use of coronary sinus sampling for left ventricular metabolic studies have been discussed.

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Section: Discussionsupporting

confidence: 57%

Thebesian Drainage of the Septal Artery

Moir

Eckstein

Driscol

1963

Circulation Research

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“…Thus, flow through the septal artery branch was not measured. This has been estimated by Eckstein et al 3 to be 16%, and by Sevelius (unpublished experiments from this laboratory) to be 9% of total left coronary inflow in the open-chest dog. In some experiments, an additional flowmeter was implanted around the ascending aorta.…”

Section: Methodsmentioning

confidence: 62%

Coronary Inflow and Oxygen Usage Following Cardiac Sympathetic Nerve Stimulation in Unanesthetized Dogs

Granata

Olsson

Huvos

et al. 1965

Circulation Research

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The effects of cardiac sympathetic nerve stimulation on coronary inflow were studied in previously operated conscious dogs, using electromagnetic flowmeters. Stimulation caused an increase of coronary inflow which was due mainly to an augmentation of flow during diastole. In systole, inflow changes were smaller and variable according to the strength of stimulation. The data presented indicate that an arteriolar dilatation may play a role in augmenting coronary inflow. In several instances, the increase of coronary inflow was preceded by a phase of reduction which suggested the possibility of coronary vasoconstriction as a primary direct effect of cardiac sympathetic activation.

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“…A reverse flow was frequently observed in early systole in the distal epicardial arteries, probably due to abrupt increase in intramyocardial pressure and fiber deformation. Earlier observations had already shown the differences of the phasic flow nature between a proximal epicardial artery and a distal or an intramural artery such as the septal artery [6,8,11,12]. In contrast to arterial flow, the small distal venous flow exhibited a systolic-predominant pattern [30], which is a characteristic of coronary vein flow [9,46].…”

Section: Introductionmentioning

confidence: 96%

Coronary microcirculation in the beating heart

Kajiya

Yada

Hiramatsu

et al. 2008

Med Biol Eng Comput

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The phase opposition of velocity waveforms between coronary arteries (predominantly diastolic) and veins (systolic) is the most prominent characteristic of coronary hemodynamics. This unique arterial and venous flow patterns indicate the importance of intramyocardial capacitance vessels and variable resistance vessels during a cardiac cycle. It was shown that during diastole the intramyocardial capacitance vessels have two functional components, unstressed volume and ordinary capacitance. Unstressed volume is defined as the volume of blood in a vessel at zero transmural pressure. In vivo observation of systolic narrowing of arterioles in mid-wall and in subendocardium indicates the increase in resistance by cardiac contraction.

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Phasic and Mean Blood Flow in the Canine Septal Artery and an Estimate of Systolic Resistance in Deep Myocardial Vessels

Cited by 30 publications

References 12 publications

Thebesian Drainage of the Septal Artery

Thebesian Drainage of the Septal Artery

Coronary Inflow and Oxygen Usage Following Cardiac Sympathetic Nerve Stimulation in Unanesthetized Dogs

Coronary microcirculation in the beating heart

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