Phase transitions in concentrated solution self-assembly of globular protein–polymer block copolymers

Lam, Christopher N.; Olsen, Bradley D.

doi:10.1039/c2sm27459k

Cited by 60 publications

(123 citation statements)

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“…Protein-polymer conjugates, for example, were created using a covalent binding maleimide-thiol coupling reaction to create bioconjugates. [33][34][35] These bioconjugates were also been used in self-assembly experiments, demonstrating the same phase diversity as related building blocks. [35] Other materials, such as polyoxometalate anionic metal-oxygen nanocages, have been successfully attached to polymer tethers via covalent bonds.…”

Section: Tethered Np Building Blocksmentioning

confidence: 99%

“…[33][34][35] These bioconjugates were also been used in self-assembly experiments, demonstrating the same phase diversity as related building blocks. [35] Other materials, such as polyoxometalate anionic metal-oxygen nanocages, have been successfully attached to polymer tethers via covalent bonds. [36,37] As these studies demonstrate, a wide range of materials are amenable to this type of modification and are experimentally accessible, opening up an enormous design space for new functional materials.…”

Section: Tethered Np Building Blocksmentioning

confidence: 99%

See 1 more Smart Citation

Rational design of nanomaterials from assembly and reconfigurability of polymer-tethered nanoparticles

2015

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Polymer-based nanomaterials have captured increasing interest over the past decades for their promising use in a wide variety of applications including photovoltaics, catalysis, optics, and energy storage. Bottom-up assembly engineering based on the self-and directed-assembly of polymer-based building blocks has been considered a powerful means to robustly fabricate and efficiently manipulate target nanostructures. Here, we give a brief review of the recent advances in assembly and reconfigurability of polymer-based nanostructures. We also highlight the role of computer simulation in discovering the fundamental principles of assembly science and providing critical design tools for assembly engineering of complex nanostructured materials.

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Section: Tethered Np Building Blocksmentioning

confidence: 99%

Section: Tethered Np Building Blocksmentioning

confidence: 99%

Rational design of nanomaterials from assembly and reconfigurability of polymer-tethered nanoparticles

2015

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“…Since the protein structure cannot be expanded, the size of the pNIPAAm-block was varied [48]. Depending on the length of the pNIPAAm in combination with the conjugate contents (wt %) and solvent quality which is controlled by the temperature, a complete phase diagram was established which displayed many of the commonly seen morphologies ranging from disordered, micellar, cylindrical to lamellar and perforated lamellar (Figure 4) [49]. (1) mChP8 (2) mChP17 (3) mChP30 (4) …”

Section: Self-assembly In Phase-separating Thin Filmsmentioning

confidence: 99%

Polymer Directed Protein Assemblies

Rijn

2013

Polymers

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Protein aggregation and protein self-assembly is an important occurrence in natural systems, and is in some form or other dictated by biopolymers. Very obvious influences of biopolymers on protein assemblies are, e.g., virus particles. Viruses are a multi-protein assembly of which the morphology is dictated by poly-nucleotides namely RNA or DNA. This "biopolymer" directs the proteins and imposes limitations on the structure like the length or diameter of the particle. Not only do these bionanoparticles use polymer-directed self-assembly, also processes like amyloid formation are in a way a result of directed protein assembly by partial unfolded/misfolded biopolymers namely, polypeptides. The combination of proteins and synthetic polymers, inspired by the natural processes, are therefore regarded as a highly promising area of research. Directed protein assembly is versatile with respect to the possible interactions which brings together the protein and polymer, e.g., electrostatic, v.d. Waals forces or covalent conjugation, and possible combinations are numerous due to the large amounts of different polymers and proteins available. The protein-polymer interacting behavior and overall morphology is envisioned to aid in clarifying protein-protein interactions and are thought to entail some interesting new functions and properties which will ultimately lead to novel bio-hybrid materials.

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“…40 Further studies of similar protein-polymer conjugates and emerging knowledge of self-assembly in the broader category of rod-coil polymers (the a-helical block is rigid while the coil block is flexible) 46 have demonstrated that the phase diagram is significantly different than that of traditional block copolymers due to the effects of chain topology and anisotropic molecular interactions. Studies on ring peptides, coiled-coils, b-sheets, and b-barrel proteins 47,48 have also shown significant differences from traditional block copolymer self-assembly for the formation of solid materials.…”

Section: Self-assembly Of Folded Protein Domainsmentioning

confidence: 97%