Phase-trafficking reagents and phase-switching strategies for parallel synthesis

A Homogeneous, Recyclable Polymer Support for Rh(I)-Catalyzed C–C Bond Formation

“…Exploiting the property of a polymer's differential solubility, phase trafficking by simple precipitation with an antisolvent can be used to recover and reuse the catalyst without appreciable loss of catalytic activity in subsequent runs. 7 …”

Lesser-Known Enabling Technologies for Organic Synthesis

“…We have used the term 'phase-switching' in this article; 46 other terms such as 'phase-trafficking' have also been used. 47 We wish to highlight strategies where the functionality responsible for the phase transition (the 'phase-tag') has been deliberately incorporated into a component in addition to the functionality required for the synthetic reaction itself. This can be distinguished from those methods (which can be defined as 'scavenging') that exploit the native reactivity of excess or unreacted reactants/reagents for their separation.…”

Identification of unprecedented purine-containing compounds, the zingerines, from ginger rhizomes (Zingiber officinale Roscoe) using a phase-trafficking approach

“…The methanolic rhizome extract was subjected to our separation protocol using ion-exchange resins allowing for fast and selective resolution of the basic, acidic, and neutral components. Solid-phase reagents (SSR) are often used to facilitate and speed-up purification procedures in organic synthesis, especially in combinatorial chemistry (Flynn, 1999; Solinas and Taddei, 2007). However, application of SSR to natural products research has been limited (Alexandratos, 2009; Vanrensen and Veit, 1995; Zhao et al, 2008).…”