Phase Stability Analysis of Chirp Evoked Auditory Brainstem Responses by Gabor Frame Operators

Abstract

We have recently shown that click evoked auditory brainstem responses (ABRs) can be efficiently processed using a novelty detection paradigm. Here, ABRs as a large-scale reflection of a stimulus locked neuronal group synchronization at the brainstem level are detected as novel instance-novel as compared to the spontaneous activity which does not exhibit a regular stimulus locked synchronization. In this paper we propose for the first time Gabor frame operators as an efficient feature extraction technique for ABR single sweep sequences that is in line with this paradigm. In particular, we use this decomposition technique to derive the Gabor frame phase stability (GFPS) of sweep sequences of click and chirp evoked ABRs. We show that the GFPS of chirp evoked ABRs provides a stable discrimination of the spontaneous activity from stimulations above the hearing threshold with a small number of sweeps, even at low stimulation intensities. It is concluded that the GFPS analysis represents a robust feature extraction method for ABR single sweep sequences. Further studies are necessary to evaluate the value of the presented approach for clinical applications.

Fast Variational Alignment of non-flat 1D Displacements for Applications in Neuroimaging

“…Also, the displacement maps in our method allow the analysis of the estimated traces (see section 3.1 and figure 9), while boosting important features in the signal average after alignment 1 . The same holds true for EP alignment: We apply our method to auditory brainstem responses (ABR) collected in Corona-Strauss et al [20]. We observe, that the diagnostically most relevant wave V [21] is easier to recognize and its amplitude is enhanced after alignment as compared to classical averaging without alignment, see figure 10.…”

A kernel-based novelty detection scheme for the ultra-fast detection of chirp evoked Auditory Brainstem Responses

“…For this purpose, the peak equivalent (pe)SPL of the chirp had to be calculated. For further details on the creation and calibration of the stimulus we refer to [10], [11]. Active Ag/AgCl electrodes (AE) (EASYCAP GmbH, Germany) were used.…”

“…Feature Extraction Gabor Frames (GFs) and Gabor Frame Phase Stability (GFPS): One part of the feature extraction stage is focused on GF decompositions, particularly in the determination of GFPS. In this paper, we only define the GFPS and we refer to [14], [10] for details. Let x denote the analytic signal of an ABR single sweep, i.e., x = s + ı Hs where s represents the original ABR single sweep waveform and H the Hilbert transform operator.…”

“…The features used in this paradigm are based on the inter-sweep instantaneous phase synchronization as well as energy and entropy relations in the time-frequency domain. Recently, [10] have shown that phase synchronization stability can be used as large-scale reflections in auditory evoked response single sweep sequences. Also it has been shown that ABRs evoked by optimized chirp signals seem to be promising as they consider the tonotopic organization of the cochlea, see [11], this means that chirps might speed up the application of the proposed detection algorithms.…”

Notched-Noise Embedded Frequency Specific Chirps for Objective Audiometry Using Auditory Brainstem Responses

“…Also, we showed recently that time-scale phase synchronization stability (PSS) provides a robust measure for the fast analysis of ABRs single sweep sequences. 42 , 43 The assessment of frequency specific ABRs could serve not only for HT determination but also for hearing aid fitting purposes, among other applications. In this paper we present the development of the notched-noise embedded band limited chirps, the resultant ABRs collected from healthy young subjects and their analysis using PSS.…”