Phase-specific Surround suppression in Mouse Primary Visual Cortex Correlates with Figure Detection Behavior Based on Phase Discontinuity

The essential role of recurrent processing for figure-ground perception in mice

“…It can therefore play a role in the segregation of small figures from the background. However, tuned suppression cannot explain FGM elicited by the phase-defined stimuli ( 20 , 42 ) described above ( Fig. 2B ) because the orientation of figure and ground is the same ( Fig.…”

“…Previous studies in freely moving mice demonstrated that mice can perceive figures that differ from the background in orientation or phase (top right and bottom left in Fig. 1A) (19,20). To address our questions, we developed a figure-ground paradigm for headfixed mice, to have sufficient control over the stimulus position relative to the mouse and simultaneously measure brain activity.…”

The essential role of feedback processing for figure-ground perception in mice

“…Previous studies in freely moving mice demonstrated that mice can perceive figures that differ from the background in orientation or phase (upper right and lower left panels in Figure 1A) (Li et al, 2018;Schnabel et al, 2018). To address our questions, we developed a figure-ground paradigm for headfixed mice, to have sufficient control over the stimulus position relative to the mouse and simultaneously measure brain activity.…”

Innovative Methodology

“…The method we developed provides a valuable, automated alternative for inferring cortical depth and laminar location of the recording sites along a silicon probe, as compared to approaches based on visual inspection of the pattern of current sinks and sources that can be derived from the LFPs recorded along the probe, as in CSD analysis (Dadarlat and Stryker 2017;Deliano et al 2018;Hansen et al 2011;Happel et al 2010;Headley and Weinberger 2015;Hoy and Niell 2015;Li et al 2018;Niell and Stryker 2008;Schroeder et al 1998Schroeder et al , 2001Sieben et al 2013;Takeuchi et al 2011). One major advantage over these approaches is that, once the template VEP profile (Fig.…”

“…Throughout the years, a technique known as "current source-density" (CSD) analysis has been widely exploited to fulfill this goal in different animal models, from monkeys (Hansen et al 2011;Schroeder et al 1998Schroeder et al , 2001Takeuchi et al 2011) to rodents (Dadarlat and Stryker 2017;Deliano et al 2018;Happel et al 2010;Headley and Weinberger 2015;Hoy and Niell 2015;Li et al 2018;Niell and Stryker 2008;Sieben et al 2013). CSD exploits the LFP gradients recorded across geometrically-arranged electrode arrays to estimate the extracellular current flow in the surrounding tissue (Nicholson and Freeman 1975).…”