Phase Separation Phenomena in Drug Systems

Naqvi, Andleeb Z.; Kabir-ud-Din, †

doi:10.1002/9781119075691.ch69

Cited by 2 publications

(2 citation statements)

References 128 publications

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“…The CAinduced depression of CP was expected because this effect has already been reported for polar organic compounds such as alkyl parabens or alkanols in C 12 E 6 solutions and Triton X-100. 39,51,52 Preferential solubilization of the hydrophobic compound into the surfactant aggregates could explain this effect because it leads first to a micellar growth and change of shape and, as a consequence, to a decrease of the CP. 39,51 As for C 12 E 4 , the aqueous solution at 25 °C is very viscous because of the formation of liquid crystals.…”

Section: Resultsmentioning

confidence: 99%

Hydrotropic Extraction of Carnosic Acid from Rosemary with Short-Chain Alkyl Polyethylene Glycol Ethers

Mazaud

Lebeuf²,

Laguerre

et al. 2020

ACS Sustainable Chem. Eng.

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Carnosic acid (CA) is a hydrophobic secondary metabolite and the main antioxidant of rosemary. Extractions of CA from whole leaves of rosemary have been performed with aqueous solutions of 12 short-chain alkyl polyethylene glycol ethers, abbreviated as C i E j with i = 4–8 and j = 1–4. Such compounds act as hydrotropes which are known to enhance the solubilization of hydrophobic molecules in water while avoiding the formation of liquid crystals like surfactants. The extractions are compared with those carried out with alcohols, sodium xylene sulfonate (SXS) which is an archetypical ionic hydrotrope, and longer C i E j (i = 10 or 12 and j = 4) which behave as true surfactants. C5E2 and C4E1 are the best candidates and provide 1.21 g/L CA in 21 h and 1.02 g/L in 8 h, respectively. They are more efficient than SXS and alcoholic aqueous solutions. Correlations between the chemical structure and activity have highlighted three requirements for better performances: (i) a small molecular volume V m (<250 Å3), (ii) a log P above 1, and (iii) a linear alkyl chain rather than a branched one. Finally, kinetic study and optical microscopy observations of the leaves after extraction give insight into the mode of action of the C4E j compared to ethanol.

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Section: Resultsmentioning

confidence: 99%

Hydrotropic Extraction of Carnosic Acid from Rosemary with Short-Chain Alkyl Polyethylene Glycol Ethers

Mazaud

Lebeuf²,

Laguerre

et al. 2020

ACS Sustainable Chem. Eng.

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“…The anionic surfactants include perfluoroalkyl surfactant LFOS, which shows an antagonistic interaction with surfactants bearing alkyl groups, resulting in a positive β value. For the Gemini surfactants [39] and bile salts [40], reviews on the interaction parameter β have recently been reported. Some compounds were excluded due to their undefined structure [41].…”

Section: Resultsmentioning

confidence: 99%

Interaction Parameters for the Formation of Mixed Micelles and Partitioning of Solutes in Them: A Review

Suzuki

2024

AppliedChem

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When two or more surfactants are mixed, the critical micelle concentration and solubilization capability are changed, and a careful selection of the combination promotes the micelle formation and enhances the solubilizing capability. Thus, understanding the mechanism behind the phenomena is essential for controlling the physical properties of the mixed micelle. The interaction parameters β and B that describe the formation of mixed micelles and their partitioning of solutes, respectively, were proposed by Treiner four decades ago. In this work, data on the formation and partitioning in binary surfactant systems were collected. Although the data on the parameters β and B for polar solutes and theoretical development are still insufficient, the directions of research to acquire an in-depth understanding of the formation and partitioning of the mixed micelle are proposed.

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Phase Separation Phenomena in Drug Systems

Cited by 2 publications

References 128 publications

Hydrotropic Extraction of Carnosic Acid from Rosemary with Short-Chain Alkyl Polyethylene Glycol Ethers

Hydrotropic Extraction of Carnosic Acid from Rosemary with Short-Chain Alkyl Polyethylene Glycol Ethers

Interaction Parameters for the Formation of Mixed Micelles and Partitioning of Solutes in Them: A Review

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