Phase Separation of Alcohol (1-Propanol, 2-Propanol, or <i>tert</i>-Butanol) from Its Aqueous Solution in the Presence of Biological Buffer MOPS

Altway, Saidah; Taha, Mohamed; Lee, Ming‐Jer

doi:10.1021/acs.jced.6b00954

Cited by 7 publications

(4 citation statements)

References 29 publications

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“…The biological buffer mechanism induces phase separation similar to that of salts. MOPS, HEPES, and EPPS are zwitterionic compounds with extremely large dipole moments and have electrostatic interactions with water. − In addition, the electrostatic interactions resulting from the zwitterionic nature of biological buffers and the van der Waals interactions of biological buffers with water are significantly greater than the interactions with solutes (butyric acid). As a result, as the ions dissolve, the interaction between water and butyric acid reduces because the molecules of water interact strongly with biological buffers and reduce the interaction of water molecules with butyric acid.…”

Section: Resultsmentioning

confidence: 99%

Liquid–Liquid Equilibria of Butyric Acid, Water, and Methyl Isobutyl Ketone with the Aid of Biological Buffer as a Green Auxiliary Agent

et al. 2023

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Biological buffer has a significant impact on aqueous organic phase equilibria in extraction processes. This study investigated the effect of biological buffer on the efficacy of butyric acid extraction from aqueous solution utilizing methyl isobutyl ketone (MIBK) as the extraction solvent. The liquid–liquid equilibria (LLE) of quaternary systems of methyl isobutyl ketone (MIBK) + butyric acid + water + biological buffer MOPS [3-(N)-morpholino propane sulfonic acid], HEPES (2-(4-(2-hydroxyethyl)-1-piperazinyl)ethanesulfonic acid), or EPPS (4-(2-hydroxyethyl)-1-piperazine propanesulfonic acid) were determined at temperature T = 303.15 K (30 °C) and P = 0.1 MPa (atmospheric pressure). The addition of EPPS to the butyric acid aqueous solution resulted in superior extraction efficacy compared to the other biological buffers, as determined by experimental data. Generally, the extraction performance was in the order EPPS > MOPS > HEPES, which represented the buffering-out strength as well. The non-random two-liquid (NRTL) and UNIversal QUAsi Chemical (UNIQUAC) models fit well with the actual LLE data of the quaternary systems. The σ-profile analysis was also evaluated in this study. Additionally, a potential process flow sheet using biological buffer and MIBK solvent was suggested for removing butyric acid from its aqueous solution.

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Section: Resultsmentioning

confidence: 99%

Liquid–Liquid Equilibria of Butyric Acid, Water, and Methyl Isobutyl Ketone with the Aid of Biological Buffer as a Green Auxiliary Agent

et al. 2023

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“…EPPS and HEPES have both hydrogen bond donor and acceptor sites. Therefore, EPPS and HEPES can strongly interact with water molecules through hydrogen bonding and electrostatic interactions [15]. Therefore, the interaction between acetic acid and water is reduced when the ions are dissolved.…”

Section: The Effect Of the Addition Of Biological Buffer On The Recovery Of Acetic Acid 321 Extraction Column Simulationmentioning

confidence: 99%

Computational study of the acetic acid extraction process from an aqueous solution with the aid of biological buffer

Altway

Ramli

Maulidia

et al. 2022

IOP Conf. Ser.: Earth Environ. Sci.

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The liquid-liquid extraction of acetic acid from an aqueous solution with 1-heptanol as an extraction solvent in the extraction column and mixer-decanter at 30°C and atmospheric pressure was simulated using Aspen Plus. A Non-Random Two-Liquid (NRTL) based model was developed by minimizing maximum-likelihood objective function. In the simulation of the extraction column and mixer-decanter, the effect of the number of stages and the flow rate of the solvent on the percent recovery can be seen. In addition, a comparison of the percent recovery value between acetic acid extraction systems using EPPS (4-(2-hydroxyehtyl)-1-piperazine propanesulfonic acid) and HEPES (4-(2-hydroxyethyl)-1 piperazineethanesulfonic acid) buffers was also carried out with systems without buffers. In this study, an economic analysis was also carried out for the acetic acid extraction system using an extraction column and a mixer-decanter. Based on the simulation results, the acetic acid extraction system with the addition of HEPES buffer using extraction column with the number of stages = 8 and solvent to feed mass ratio = 1.6 was the most optimal and efficient extraction process obtained in this study. This system has the capital cost of 180,729,262.67 USD with the percent recovery up to 99.83% and the mass fraction of acetic acid in the raffinate phase is 0.0002 which is also extremely low.

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“…The solubility of the mixed solutions will be changed after the addition of inorganic salts. It will make the phase separation easier, and achieve the conditions required for extraction. − Therefore, the salting-out effect can be effectively applied to the liquid–liquid phase separation. Pimentel et al obtained equilibrium data for 2-propanol/water solutions after the addition of sodium sulfate and magnesium sulfate.…”

Section: Introductionmentioning

confidence: 99%

Effects of Inorganic Salts on the Phase Separation of Partially Miscible Solutes

Zhao,

Ding,

Zhu

et al. 2024

Langmuir

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Partially miscible solutions with a lower critical solution temperature have promising applications in the field of physical chemistry. To better guide the utilization of these solutions in practice, we conduct an in-depth study about the phase separation behavior of the solution added with inorganic salts. The addition of the inorganic salts into the solution is found to consequently reduce the phase separation temperature. The variation of concentrations of inorganic salts does not notably affect the mass fraction of the separation. Moreover, the addition of inorganic salts in the solutions at lower mass fractions improves the separation mass fraction, while the addition of inorganic salts decreases the separation mass fraction at the mass fractions above 30%. It sheds light on selecting the proper mass fractions and inorganic salt concentrations. Furthermore, we explore the phase separation behavior of mixed solutions under different inorganic salt additions by means of a high-speed camera. The phase separation behavior under different inorganic salt systems shows a similar trend. However, calcium ions and Fe3+ ions in the solutions can greatly decrease the rate of droplet coalescence and result in an increase in phase separation. For better regulating the solutions with a lower critical solution temperature through inorganic salts, sodium chloride or potassium chloride is recommended with an appropriate concentration.

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Phase Separation of Alcohol (1-Propanol, 2-Propanol, or tert-Butanol) from Its Aqueous Solution in the Presence of Biological Buffer MOPS

Cited by 7 publications

References 29 publications

Liquid–Liquid Equilibria of Butyric Acid, Water, and Methyl Isobutyl Ketone with the Aid of Biological Buffer as a Green Auxiliary Agent

Liquid–Liquid Equilibria of Butyric Acid, Water, and Methyl Isobutyl Ketone with the Aid of Biological Buffer as a Green Auxiliary Agent

Computational study of the acetic acid extraction process from an aqueous solution with the aid of biological buffer

Effects of Inorganic Salts on the Phase Separation of Partially Miscible Solutes

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