Phase-resolved magnetomotive OCT for imaging nanomolar concentrations of magnetic nanoparticles in tissues

Oldenburg, Amy L.; Crecea, Vasilica; Rinne, Stephanie A.; Boppart, Stephen A.

doi:10.1364/oe.16.011525

Cited by 87 publications

(32 citation statements)

References 27 publications

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“…To that end, the ability of MNPs to provide single and multimodal in vivo images has been exploited by combining other techniques like optical coherence tomography (OCT), MRI, computed tomography (CT), and photoacoustic (PA) imaging. [33][34][35][36][37][38][39] MNPs have also been combined with near-infrared (NIR)-emitting nanoparticles (NPs) in a single hybrid structure, allowing multimodal imaging via NIR fluorescence and MRI. [40,41] On the other hand, precise, real-time thermal feedback is needed for determining the delivered heat dose and for the dynamical setting of the treatment parameters.…”

Section: Introductionmentioning

confidence: 99%

Infrared‐Emitting Multimodal Nanostructures for Controlled In Vivo Magnetic Hyperthermia

et al. 2021

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Deliberate and local increase of the temperature within solid tumors represents an effective therapeutic approach. Thermal therapies embrace this concept leveraging the capability of some species to convert the absorbed energy into heat. To that end, magnetic hyperthermia (MHT) uses magnetic nanoparticles (MNPs) that can effectively dissipate the energy absorbed under alternating magnetic fields. However, MNPs fail to provide real‐time thermal feedback with the risk of unwanted overheating and impeding on‐the‐fly adjustment of the therapeutic parameters. Localization of MNPs within a tissue in an accurate, rapid, and cost‐effective way represents another challenge for increasing the efficacy of MHT. In this work, MNPs are combined with state‐of‐the‐art infrared luminescent nanothermometers (LNTh; Ag2S nanoparticles) in a nanocapsule that simultaneously overcomes these limitations. The novel optomagnetic nanocapsule acts as multimodal contrast agents for different imaging techniques (magnetic resonance, photoacoustic and near‐infrared fluorescence imaging, optical and X‐ray computed tomography). Most crucially, these nanocapsules provide accurate (0.2 °C resolution) and real‐time subcutaneous thermal feedback during in vivo MHT, also enabling the attainment of thermal maps of the area of interest. These findings are a milestone on the road toward controlled magnetothermal therapies with minimal side effects.

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Section: Introductionmentioning

confidence: 99%

Infrared‐Emitting Multimodal Nanostructures for Controlled In Vivo Magnetic Hyperthermia

et al. 2021

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“…It has been suggested that the opposed motion is a result of a diamagnetic response of tissue (or phantom material), free from magnetic nanoparticles. Because tissue is mainly diamagnetic, it would normally be displaced in the opposite direction as compared with SPIONs under the influence of a magnetic field (Oldenburg et al 2008). This is an interesting hypothesis but in our previous phantom experiments we were unable to measure any diamagnetic effect in phantoms free from SPIONs (Evertsson et al 2013), and this type of motion outside of the targeted area was less distinct when the technique was applied to an animal model (Evertsson et al 2014).…”

Section: Introductionmentioning

confidence: 91%

Displacement Patterns in Magnetomotive Ultrasound Explored by Finite Element Analysis

Sjöstrand

Evertsson

Atile

et al. 2022

Ultrasound in Medicine & Biology

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“…In magnetomotive OCT, magnetic micro-or nanoparticles are used as dynamic contrast agents, which are exited into motion by an external magnetic field. Contrast enhancement is then achieved by quantifying the displacement of the elastic tissue next to the particles using the amplitude or phase information of the OCT signal (Oldenburg et al 2005a(Oldenburg et al , 2008. In this context, it was shown that magnetomotive OCT is a suitable method for contrastenhanced imaging of single magnetically labeled cells in vitro (Oldenburg et al 2005b).…”

Section: Contrast Enhancement By Nanoparticles: Photothermal Oct and Magnetomotive Octmentioning

confidence: 99%

Optical Imaging

Alves

Bode

Cimalla

et al. 2017

Small Animal Imaging

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Phase-resolved magnetomotive OCT for imaging nanomolar concentrations of magnetic nanoparticles in tissues

Cited by 87 publications

References 27 publications

Infrared‐Emitting Multimodal Nanostructures for Controlled In Vivo Magnetic Hyperthermia

Infrared‐Emitting Multimodal Nanostructures for Controlled In Vivo Magnetic Hyperthermia

Displacement Patterns in Magnetomotive Ultrasound Explored by Finite Element Analysis

Optical Imaging

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