Phase-resolved detection in ion-mobility spectrometry

Szumlas, Andrew W.; Hieftje, Gary M.

doi:10.1016/j.aca.2006.02.036

Cited by 12 publications

(9 citation statements)

References 23 publications

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“…Data were acquired over the range m/z 500-4000 for 2 min per each acquisition. Mass calibration was performed by a separate infusion of horse heart myoglobin (16,951.49 Da). Data processing was carried out using the MassLynx v. 4.1 software supplied with the Synapt HDMS.…”

Section: Esi-twims-msmentioning

confidence: 99%

“…conversely, its shortcoming has been its low sensitivity, on account of the inefficient transfer of ions from ambient pressure into the high vacuum of the mass spectrometer; the ion gate allowing ions to enter the mass spectrometer is open for only ~1% of the duty cycle and, thus, 99% of the sample is discarded when a continuous ionisation source such as electrospray is used. 9,16 High field asymmetric waveform ion mobility spectrometry-mass spectrometry An alternative approach to conventional IMS is that of differential mobility, or high field asymmetric waveform IMS (fAIMS), in which an alternating asymmetric high/low electric field is applied between two electrodes. An ion's mobility is now not proportional to the electric field, but to the difference in mobilities that it experiences between the two fields.…”

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confidence: 99%

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Deciphering Drift Time Measurements from Travelling Wave Ion Mobility Spectrometry-Mass Spectrometry Studies

Smith

Knapman

Campuzano

et al. 2009

Eur J Mass Spectrom (Chichester)

322

384

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Detailed knowledge of the tertiary and quaternary structure of proteins and protein complexes is of immense importance in understanding their functionality. Similarly, variations in the conformational states of proteins form the underlying mechanisms behind many biomolecular processes, numerous of which are disease-related. Thus, the availability of reliable and accurate biophysical techniques that can provide detailed information concerning these issues is of paramount importance. Ion mobility spectrometry (IMS) coupled to mass spectrometry (MS) offers a unique opportunity to separate multi-component biomolecular entities and to measure the molecular mass and collision cross-section of individual components in a single, rapid (

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Section: Esi-twims-msmentioning

confidence: 99%

mentioning

confidence: 99%

Deciphering Drift Time Measurements from Travelling Wave Ion Mobility Spectrometry-Mass Spectrometry Studies

Smith

Knapman

Campuzano

et al. 2009

Eur J Mass Spectrom (Chichester)

322

384

View full text Add to dashboard Cite

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“…There is another modulate manner which is based on phase-resolved (PR) detection that is applied by Szumlas and Hieftje [23]. In the PR-IMS, a sinusoidal or multi-frequency function is used to continuously modulate ion gate based on a traditional configuration.…”

Section: Methods Based On Phase-resolved Detectionmentioning

confidence: 99%

Progress on Ion Beam Modulation Technique for Time-Dependent Analytical Instruments

Zhang

Xiaolin

2010

2010 First International Conference on Pervasive Computing, Signal Processing and Applications

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Both Time-of-flight (TOF) mass spectrometry and ion mobility spectrometry (IMS) are time-dependent analytical instruments which need to quickly and efficiently chop continuous ion beam into small packets for separation based on ion gates device. The effect of ion beam modulation technique can affect to some extent the performance of these instruments, such as resolution or sensitivity. So ion gates are a very important component of these instruments and ion beam modulation methods are key technique of such instruments. This review provides a development of ion beam modulation methods based on ion gates in TOF and IMS and a performance comparison between them.

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“…[26][27][28][29] This mode of operation does not require any hardware specific modifications to implement and given the range of Hadamard sequences available is readily adapted to a range of drift tube ion mobility experiments. Though outside the scope of this discussion, other notable multiplexing approaches to IMS experiments include the use of modified pseudo-random sequences, 28,30 Barker codes, 31 phase-modulated IMS, 32 and most recently overtone mobility spectrometry (OMS). 33,34 In all cases, the primary focus is to enhance ion throughput and maximize signal to noise ratio for a technique that has historically be challenged by low duty-cycles.…”

Section: Introductionmentioning

confidence: 99%

A two-phase approach to fourier transform ion mobility time-of-flight mass spectrometry

Clowers

Siems

et al. 2015

Analyst

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It is well known that the duty cycle of common drift-tube ion mobility experiments is often below 1%. However, multiplexing approaches such as Fourier and Hadamard pulsing schemes have been shown to independently enhance the throughput of ion mobility spectrometry (IMS) experiments to levels that approach 50%. While challenges remain to their broad scale implementation we describe a new Fourier transform (FT) IMS experiment that is directly compatible with standard drift tube ion mobility mass spectrometers (DT-IMMS). Compared to previous FT-IMS experiments, our new approach requires only a single gate and circumvents the need for signal apodization by combining data from two frequency pulsing sequences 180° out of phase. Assessment of our initial results highlights an increase in signal-to-noise (SNR) relative to both previous implementations FT-IMS experiments and signal averaged (SA) experiments. For select tetraalkylammonium salts SNR improvements of more than one order of magnitude are routinely possible. To explore the performance metrics associated with the technique a number of experimental variables were systematically altered including frequency sweep range, sweep time, and data acquisition time. Using this experimental design we present the key aspects, considerations, and minimum resources necessary for other IMS researchers to incorporate this operational mode into their research. The two-phase FT-IMMS technique offers a tractable mechanism to enhance sensitivity for IMMS measurements and its broad-scale adoption by IMMS researchers promises to enhance the acquisition speed for mobility measurements using hybrid instrumentation.

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Phase-resolved detection in ion-mobility spectrometry

Cited by 12 publications

References 23 publications

Deciphering Drift Time Measurements from Travelling Wave Ion Mobility Spectrometry-Mass Spectrometry Studies

Deciphering Drift Time Measurements from Travelling Wave Ion Mobility Spectrometry-Mass Spectrometry Studies

Progress on Ion Beam Modulation Technique for Time-Dependent Analytical Instruments

A two-phase approach to fourier transform ion mobility time-of-flight mass spectrometry

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