Phase relationships support a role for coordinated activity in the indirect pathway in organizing slow oscillations in basal ganglia output after loss of dopamine

Walters, Judith R.; Hu, Dan; Itoga, Christy A.; Parr‐Brownlie, Louise C.; Bergstrom, Debra A.

doi:10.1016/j.neuroscience.2006.10.006

Cited by 126 publications

(179 citation statements)

References 81 publications

(148 reference statements)

Supporting

Mentioning

150

Contrasting

Order By: Relevance

“…Consistent with this phenomenon, increases in burstiness and oscillatory activity have been shown in spike trains of several basal ganglia nuclei following dopamine cell lesion in the anesthetized rat model of PD (Sanderson et al, 1986;MacLeod et al, 1990;Hollerman and Grace, 1992;Burbaud et al, 1995;Hassani et al, 1996;Murer et al, 1997;Rohlfs et al, 1997;Magill et al, 2000;Tseng et al, 2000Tseng et al, , 2001aPerier et al, 2000;Vila et al, 2000;Ni et al, 2001;Belluscio et al, 2003;Tai et al, 2003;Walters et al, 2005Walters et al, , 2007Parr-Brownlie et al, 2007;Zold et al, 2007).…”

Section: Predicted Effect Of Basal Ganglia Output On Ppn Activity Aftsupporting

confidence: 55%

“…The effect of dopamine cell lesion on PPN and MCx LFP activity-Slow ∼1 Hz oscillations that emerge in LFP and spike trains in the basal ganglia of urethane-anesthetized rats after dopamine cell lesion have been shown to be highly coherent with slow oscillations in cortical activity (Magill et al, 2001;Tseng et al, 2001b;Belluscio et al, 2003;ParrBrownlie et al, 2007;Walters et al, 2007;Zold et al, 2007). In the present study, PPN LFPs were significantly coherent with MCx LFPs in the ∼1 Hz range (0.3-2.5 Hz) in intact rats (0.65 ± 0.03, n=10 rats) and lesioned rats (0.52 ± 0.06, n=11 rats) ( Fig.…”

Section: Ppn and MCX Spike And Lfp Relationships In The Urethane-anesmentioning

confidence: 99%

“…Cortical activity in the urethane-anesthetised rat is highly synchronized, characteristically oscillates at ∼1Hz, and is relatively stable over time (Steriade et al, 1993;Steriade, 1995, 1997;Amzica and Steriade, 1998). Many studies have shown changes in firing pattern and increased oscillatory activity in the basal ganglia following dopamine cell lesion in the anesthetized rat (Sanderson et al, 1986;MacLeod et al, 1990;Hollerman and Grace, 1992;Burbaud et al, 1995;Hassani et al, 1996;Murer et al, 1997;Rohlfs et al, 1997;Tseng et al, 2000Tseng et al, , 2001aTseng et al, , 2001bPerier et al, 2000;Vila et al, 2000;Magill et al, 2001;Ni et al, 2001;Belluscio et al, 2003;Tai et al, 2003;Walters et al, 2005Walters et al, , 2007Parr-Brownlie et al, 2007;Zold et al, 2007). Recently, this cortical oscillatory activity has been used as a probe signal in the urethane-anesthetized rat to investigate the effects of dopamine loss on the phase relationships between oscillatory activity in the external segment of the globus pallidus (GPe), the substantia nigra pars reticulata (SNpr), the subthalamic nucleus (STN), and the striatum .…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Altered neuronal activity relationships between the pedunculopontine nucleus and motor cortex in a rodent model of Parkinson's disease

Aravamuthan

Bergstrom

French

et al. 2008

Experimental Neurology

View full text Add to dashboard Cite

The pedunculopontine nucleus (PPN) is a new deep brain stimulation (DBS) target for Parkinson's disease (PD), but little is known about PPN firing pattern alterations in PD. The anesthetized rat is a useful model for investigating the effects of dopamine loss on the transmission of oscillatory cortical activity through basal ganglia structures. After dopamine loss, synchronous oscillatory activity emerges in the subthalamic nucleus and substantia nigra pars reticulata in phase with cortical slow oscillations. To investigate the impact of dopamine cell lesion-induced changes in basal ganglia output on activity in the PPN, this study examines PPN spike timing with reference to motor cortex (MCx) local field potential (LFP) activity in urethane-and ketamine-anesthetized rats. Seven -ten days after unilateral 6-hydroxydopamine lesion of the medial forebrain bundle, spectral power in PPN spike trains and coherence between PPN spiking and PPN LFP activity increased in the ∼1 Hz range in urethane-anesthetized rats. PPN spike timing also changed from firing predominantly in-phase with MCx slow oscillations in the intact urethane-anesthetized rat to firing predominantly antiphase to MCx oscillations in the hemi-parkinsonian rat. These changes were not observed in the ketamine-anesthetized preparation. These observations suggest that dopamine loss alters PPN spike timing by increasing inhibitory oscillatory input to the PPN from basal ganglia output nuclei, a phenomenon that may be relevant to motor dysfunction and PPN DBS efficacy in PD patients.

show abstract

Section: Predicted Effect Of Basal Ganglia Output On Ppn Activity Aftsupporting

confidence: 55%

Section: Ppn and MCX Spike And Lfp Relationships In The Urethane-anesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Altered neuronal activity relationships between the pedunculopontine nucleus and motor cortex in a rodent model of Parkinson's disease

Aravamuthan

Bergstrom

French

et al. 2008

Experimental Neurology

View full text Add to dashboard Cite

show abstract

“…In addition, many existing studies show contrasting tendencies to increasing or to decreasing firing rate in STN after lesion of the SNc (Hassani et al, 1996;Hollerman and Grace, 1992;Magill et al, 2001;Ni et al, 2001;Vila et al, 2000). We observed a decrease in the relative number of OSC cell types, in contrast with an increase in the incidence of slow oscillations (0.3-2.5 Hz) reported by Walters et al (2007) after dopamine cell lesion in urethane-anesthetized rats. A possible source of discrepancy with previous studies may arise from the use of different anesthesia.…”

Section: Discussioncontrasting

confidence: 40%

Dopamine deficiency increases synchronized activity in the rat subthalamic nucleus

Lintas¹,

Силькис²,

Albèri³

et al. 2012

Brain Research

View full text Add to dashboard Cite

Abnormal neuronal activity in the subthalamic nucleus (STN) plays a crucial role in the pathophysiology of Parkinson's disease (PD). In this study we investigated changes in rat STN neuronal activity after 28 days following the injection of 6-OHDA in the substantia nigra pars compacta (SNc). This drug provoked a lesion of SNc that induced a dopamine and lesioned (n = 83) groups was similar, as well as the firing rate. In 6-OHDA treated rats we observed a significant increase (from 26% to 48%) in the number of pairs with synchronous firing. These data suggest that the synchronous activity of STN cells, provoked by loss of DA cells in SNc, is likely to be among the most significant dysfunctions in the basal ganglia of Parkinsonian patients. We raise the hypothesis that in normal conditions, DA maintains a balance between funneling information via the hyperdirect cortico-subthalamic pathway and parallel processing through the parallel cortico-basal ganglia-subthalamic pathways, both of which are necessary for selected motor behaviors..

show abstract

“…However, the discharge pattern that we observed would be consistent with a highly selective and short term signal such as attention that we might expect to be conveyed by striatal medium spiny neurons that are modulated by dopamine. The preferential modulation that we observed during cued movement could also reflect a combination of factors such as cumulative changes in GPi firing pattern, oscillation, or synchronization of neurons within a neural network, all of which could be modulated by dopamine influences (Bergman et al, 1998;Ruskin et al, 2003;Walters et al, 2007). Some of these factors may be directly related to the selection or generation of the movement required by the task, but could perhaps be more indicative of signaling related to the suppression or facilitation of non-task related movements (Mink, 1996).…”

Section: Possible Factors That May Influence Context-dependent Dischargementioning

confidence: 89%

Signaling patterns of globus pallidus internal segment neurons during forearm rotation

et al. 2007

View full text Add to dashboard Cite

We recorded extracellular single unit discharges of globus pallidus internal segment (GPi) neurons in monkeys performing a visually-driven forearm rotation movement task in order to quantify how discharge patterns changed in relation to kinematic parameters. Subjects grasped a handle that rotated about its axis while facing a video screen displaying visual targets. Continuous visual feedback of handle rotation position was provided. Monkeys generated forearm rotation movements of ±35° and ±70° amplitude in order to align the cursor and targets. Trial records were aligned to forearm rotation onset in order to compare the discharge patterns that were associated with movements of different amplitudes, velocities, and directions. In addition, we quantified the depth of modulation of neuronal discharge associated with movements generated in two different task phases. Comparisons of discharge patterns were made between the visually-guided, rewarded phase ("cued movements") and the self-paced, unrewarded phase that returned the monkey to the task start position ("return movements") by quantifying the goodness of fit between neuronal discharge during cued and return movements.Our analyses revealed no systematic relationship between the depth of modulation of GPi neurons and forearm rotation amplitude, direction, or velocity. Further, comparisons between the two behavioral contexts revealed a systematic attenuation of modulation that could not be attributed to differences in movement velocity. Collectively, these findings suggest that the GPi neurons that we studied were not significantly involved in mediating movement kinematics, but may have instead been instrumental in the processing of information about the behavioral context during which movements were generated.

show abstract

Phase relationships support a role for coordinated activity in the indirect pathway in organizing slow oscillations in basal ganglia output after loss of dopamine

Cited by 126 publications

References 81 publications

Altered neuronal activity relationships between the pedunculopontine nucleus and motor cortex in a rodent model of Parkinson's disease

Altered neuronal activity relationships between the pedunculopontine nucleus and motor cortex in a rodent model of Parkinson's disease

Dopamine deficiency increases synchronized activity in the rat subthalamic nucleus

Signaling patterns of globus pallidus internal segment neurons during forearm rotation

Contact Info

Product

Resources

About