Phase precession in the human hippocampus and entorhinal cortex

Qasim, Salman E.; Fried, Itzhak; Jacobs, Joshua

doi:10.1016/j.cell.2021.04.017

Cited by 94 publications

(99 citation statements)

References 117 publications

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“…In sum, this demonstrates that hippocampal phase coding is not restricted to place cell firing during active movement or to sustained low-frequency oscillations with relatively constant rhythmicity, consistent with a growing body of experimental work across species. 12 , 15 , 16 , 17 , 18 …”

Section: Discussionmentioning

confidence: 99%

“… 11 , 12 , 29 , 30 , 31 More generally, the multiplexing of information in firing rate and phase could allow for much richer coding of task-relevant variables in the human brain across a range of network states and cognitive domains. 18 , 41 , 42 , 43 , 44 …”

Section: Discussionmentioning

confidence: 99%

“…Importantly, however, phase is independent of frequency, and a similar coding scheme could therefore be supported by oscillatory activity in other frequency bands, such as 25- to 55-Hz slow gamma, 13 , 14 , 15 or by an LFP signal whose instantaneous frequency varies dynamically over a wide range, such as that observed in bats and humans. 12 , 16 , 17 , 18 During periods of quiescent waking and rest, the hippocampal LFP exhibits prominent sharp-wave ripple (SWR) events composed of a large-amplitude deflection accompanied by a transient increase in 150- to 250-Hz ripple band power. 19 SWR events are associated with prominent place cell multi-unit activity (MUA), which can recapitulate coherent spatial trajectories through recently visited environments.…”

Section: Introductionmentioning

confidence: 99%

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Ripple band phase precession of place cell firing during replay

Bush

Ólafsdóttir

Barry³

et al. 2022

Current Biology

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Summary Neuronal “replay,” in which place cell firing during rest recapitulates recently experienced trajectories, is thought to mediate the transmission of information from hippocampus to neocortex, but the mechanism for this transmission is unknown. Here, we show that replay uses a phase code to represent spatial trajectories by the phase of firing relative to the 150- to 250-Hz “ripple” oscillations that accompany replay events. This phase code is analogous to the theta phase precession of place cell firing during navigation, in which place cells fire at progressively earlier phases of the 6- to 12-Hz theta oscillation as their place field is traversed, providing information about self-location that is additional to the rate code and a necessary precursor of replay. Thus, during replay, each ripple cycle contains a “forward sweep” of decoded locations along the recapitulated trajectory. Our results indicate a novel encoding of trajectory information during replay and implicates phase coding as a general mechanism by which the hippocampus transmits experienced and replayed sequential information to downstream targets.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Ripple band phase precession of place cell firing during replay

Bush

Ólafsdóttir

Barry³

et al. 2022

Current Biology

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“…But many other methods are possible. For example, a recent study demonstrated phase precession in humans when using the phase of clocking oscillations as the time axis, with the same findings absent in clock time [42]. Another way is to sort data into phase bins [19], or to lock analyses to the peak or trough of clocking oscillations, rather than to clock time events such as responses or stimuli.…”

Section: Other Ways To Account For Disharmonymentioning

confidence: 99%

“…More extensive approaches include locking analyses to oscillatory peaks or troughs [44], linear warping algorithms [45], and re-sorting data with phase as the time axis. Interestingly, the latter method has been used to demonstrate phase precession in humans, results which were absent when the analysis was performed in clock time [46].…”

Section: Other Ways To Account For Disharmonymentioning

confidence: 99%

The Brain Time Toolbox, a software library to retune electrophysiology data to brain dynamics

Bree

Melcón

Kolibius

et al. 2021

Preprint

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Human thought is highly flexible and dynamic, achieved by evolving patterns of brain activity across groups of cells. Neuroscience aims to understand cognition in the brain by analysing these intricate patterns. Here, we argue that this goal is impeded by the time format of our data – clock time. The brain is a system with its own dynamics and regime of time, with no intrinsic concern for the human-invented second. A more appropriate time format is cycles of brain oscillations, which coordinate neural firing and are widely implicated in cognition. These brain dynamics do not obey clock time – they start out of tune with clock time and drift apart even further as oscillations unpredictably slow down, speed up, and undergo abrupt changes. Since oscillations clock cognition, their dynamics should critically inform our analysis. We describe brain time warping as a new method to transform data in accordance with brain dynamics, which sets the time axis to cycles of clocking oscillations (a native unit) rather than milliseconds (a foreign unit). We also introduce the Brain Time Toolbox, a software library that implements brain time warping for electrophysiology data and tests whether it reveals information patterns in line with how the brain uses them.

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Hippocampal spatial view cells for memory and navigation, and their underlying connectivity in humans

Rolls

2022

Hippocampus

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Hippocampal and parahippocampal gyrus spatial view neurons in primates respond to the spatial location being looked at. The representation is allocentric, in that the responses are to locations "out there" in the world, and are relatively invariant with respect to retinal position, eye position, head direction, and the place where the individual is located. The underlying connectivity in humans is from ventromedial

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Phase precession in the human hippocampus and entorhinal cortex

Cited by 94 publications

References 117 publications

Ripple band phase precession of place cell firing during replay

Ripple band phase precession of place cell firing during replay

The Brain Time Toolbox, a software library to retune electrophysiology data to brain dynamics

Hippocampal spatial view cells for memory and navigation, and their underlying connectivity in humans

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