“…Multiple randomized studies revealed that combined modality treatment (RT plus chemotherapy) has superior outcomes and less toxicity to RT alone. Of importance are the two randomized studies by Press et al (Press, LeBlanc, Lichter, et al, 2001) and Engert et al (Engert, Franklin, Eich, et al, 2007) which compared RT alone in early stage favorable HL to combined modality with chemotherapy followed by RT. Press el al compared 3 cycles of chemotherapy (doxorubicin + vinblastine) followed by subtotal lymphoid irradiation (STLI) to STLI alone with freedom from treatment failure (FFTF) of 94% vs. 81% after 3 years of follow up in favor to combined modality arm.…”