Phase III randomised chemoprevention study with selenium on the recurrence of non-invasive urothelial carcinoma. The SELEnium and BLAdder cancer Trial

Goossens, Maria E.; Poppel, Hendrik Van; Joniau, Steven; Ackaert, Koen; Billiet, Ignace; Braeckman, Johan; Breugelmans, Alex; Darras, Jochen; Dilen, Kurt; Goeman, Lieven; Tombal, Bertrand; Bruwaene, Siska Van; Cleyenbreugel, Ben Van; Aa, Frank Van der; Vekemans, K.; Buntinx, Frank

doi:10.1016/j.ejca.2016.09.021

Cited by 19 publications

(20 citation statements)

References 31 publications

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“…Fourteen dietary supplementation studies in UBC patients were identified ( Table 3 ). In these randomized controlled trials, the effects of the retinoids etretinate [ 13, 32, 35 ] and fenretinide [ 20, 34 ], vitamin B6 (pyridoxine) [ 17, 31 ], vitamin E (tocopherol) [ 26 ], multivitamins [ 24, 30 ], a Lactobacillus casei preparation [ 14, 28, 41 ], and selenium [ 21 ] were investigated. Thirteen of the 14 studies were performed in NMIBC patients [ 13, 14, 17, 20, 21, 26, 28, 30–32, 34, 35, 41 ] and one trial was conducted in NMIBC and MIBC patients combined [ 24 ].…”

Section: Resultsmentioning

confidence: 99%

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Body Mass Index, Diet-Related Factors, and Bladder Cancer Prognosis: A Systematic Review and Meta-Analysis

Westhoff¹,

Witjes

Fleshner

et al. 2018

BLC

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Background:Urologists are frequently confronted with questions of urinary bladder cancer (UBC) patients about what they can do to improve their prognosis. Unfortunately, it is largely unknown which lifestyle factors can influence prognosis.Objective:To systematically review the available evidence on the association between body mass index (BMI), diet, dietary supplements, and physical activity and UBC prognosis.Methods:We searched PubMed and Embase up to May 2017. We included thirty-one articles reporting on observational and randomized controlled trials investigating BMI, diet and dietary supplements in relation to recurrence, progression, cancer-specific or all-cause mortality in UBC patients.Results:In non-muscle invasive bladder cancer (NMIBC) patients, both overweight (3 studies, pooled hazard ratio (HR) 1.29, 95% CI 1.05–1.58, I2 = 0%) as well as obesity (3 studies, pooled HR 1.82, 95% CI 1.12–2.95, I2 = 79%) were associated with increased risk of recurrence when compared to normal weight. No association of BMI with risk of progression was found. Results for BMI and prognosis in muscle-invasive or in all stages series were inconsistent. Observational studies on diet and randomized controlled trials with dietary supplements showed inconsistent results. No studies on physical activity and UBC prognosis have been published to date.Conclusions:Evidence for an association of lifestyle factors with UBC prognosis is limited, with some evidence for an association of BMI with risk of recurrence in NMIBC. Well-designed, prospective studies are needed to develop evidence-based guidelines on this topic.

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Section: Resultsmentioning

confidence: 99%

“…A study in 292 NMIBC patients conducted in Belgium showed that selenium supplementation did not lower the risk of recurrence compared to placebo [ 21 ].…”

Section: Resultsmentioning

confidence: 99%

Body Mass Index, Diet-Related Factors, and Bladder Cancer Prognosis: A Systematic Review and Meta-Analysis

Westhoff¹,

Witjes

Fleshner

et al. 2018

BLC

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“…cardiovascular diseases, and therefore reduction of ROS by antioxidants is not a cure (Hantikainen et al., ; Pagliaro & Penna, ). Although the same applies to other diseases, such as cancer or dementia (Goossens et al., ; Kryscio et al., ), the concept of ROS, NADPH oxidases and oxidative stress as the cause, and treatment with antioxidant as a potential cure of diseases, is stable, although this concept is also widely questioned (Schmidt et al., ; Scudellari, ).…”

Section: Nadph Oxidases: a Double‐edged Sword Of Signalling And Damagementioning

confidence: 99%

NADPH oxidase‐derived reactive oxygen species: Dosis facit venenum

Schröder

2019

Experimental Physiology

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New Findings What is the topic of this review? Within this review, the role of reactive oxygen species in cellular homeostasis, physiology and pathophysiology is discussed. What advances does it highlight? The review provides new concepts of how reactive oxygen species influence gene expression, energy consumption and other aspects of the life of a cell. Furthermore, a model is provided to illustrate how reactive oxygen species elicit specific oxidation of target molecules. Abstract Reactive oxygen species (ROS) have a long history of bad reputation. They are needed and effective in host defense, but on the contrary may induce situations of oxidative stress. Besides that, within recent years several soft functions (functions that may occur and are not directly connected to an effect, but may influence signaling in an indirect manner) of NADPH oxidases have been discovered, which are slowly eroding the image of the solely dangerous ROS. NADPH oxidase‐derived ROS serve to ease or enable signal transduction and to maintain homeostasis. However, there is still an enormous lag in the knowledge concerning target proteins and how ROS can elicit specific signalling in different cells and tissues. The present review summarizes some important functions of Nox2 and Nox4. Furthermore, although highly speculative, a model is provided of how those NADPH oxidases might be able to oxidize target proteins in a specific way. Many concepts mentioned in this review represent my personal view and are supported only in part by published studies.

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“…Another study reported that synthetic vitamin B9 (folate) may be associated with increased risk of recurrence (HR 1.80 in tertile 3 compared to tertile 1, 95% CI 1.14-2.84) [101]. Evidence leans toward questionable to no benefit from supplemental vitamin A, [51,[102][103][104][105][106] vitamin B6, [91,92] selenium, [93] and megadose multivitamin formulations [98,99]. Multiple RCTs have investigated the effect of synthetic retinoids like fenretinide [102,103] and etretinate on NMIBC outcomes [104][105][106].…”

Section: Diet and Supplementsmentioning

confidence: 99%

Lifestyle and Non-muscle Invasive Bladder Cancer Recurrence, Progression, and Mortality: Available Research and Future Directions

Zuniga

Graff

Feiger

et al. 2020

BLC

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BACKGROUND: A broad, comprehensive review of studies exploring associations between lifestyle factors and non-muscle invasive bladder cancer (NMIBC) outcomes is warranted to consolidate recommendations and identify gaps in research. OBJECTIVE: To summarize the literature on associations between lifestyle factors and clinical outcomes among patients with NMIBC. METHODS: PubMed was systematically queried for articles published through March 2019 regarding lifestyle factors and recurrence, progression, cancer-specific mortality, and all-cause mortality among patients with NMIBC. RESULTS: Notwithstanding many ambiguities, there is good-quality evidence suggesting a benefit of smoking avoidance/cessation, healthy body mass index (BMI), and type II diabetes mellitus prevention and treatment. Lactobacillus casei probiotic supplementation may reduce recurrence. There have been individual studies suggesting a benefit for uncooked broccoli and supplemental vitamin E as well as avoidance of supplemental vitamin B9, areca nut chewing, and a "Western diet" pattern high in fried foods and red meat. Additional studies do not suggest associations between NMIBC outcomes and use of fibrin clot inhibitors; insulin and other oral hypoglycemics; statins; supplemental selenium, vitamin A, vitamin C, and vitamin B6; fluid intake and intake of specific beverages (e.g., alcohol, coffee, green tea, cola); various dietary patterns (e.g., Tex-Mex, high fruit and vegetable, low-fat); and occupational and chemical exposures. CONCLUSIONS: Despite a myriad of publications on lifestyle factors and NMIBC, a need remains for research on unexplored associations (e.g., physical activity) and further studies that can elucidate causal effects. This would inform future implementation strategies for healthy lifestyle change in NMIBC patients.

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Phase III randomised chemoprevention study with selenium on the recurrence of non-invasive urothelial carcinoma. The SELEnium and BLAdder cancer Trial

Cited by 19 publications

References 31 publications

Body Mass Index, Diet-Related Factors, and Bladder Cancer Prognosis: A Systematic Review and Meta-Analysis

Body Mass Index, Diet-Related Factors, and Bladder Cancer Prognosis: A Systematic Review and Meta-Analysis

NADPH oxidase‐derived reactive oxygen species: Dosis facit venenum

Lifestyle and Non-muscle Invasive Bladder Cancer Recurrence, Progression, and Mortality: Available Research and Future Directions

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