Phase II Trial of Preoperative Chemoradiation in Patients With Localized Gastric Adenocarcinoma (RTOG 9904): Quality of Combined Modality Therapy and Pathologic Response

Ajani, Jaffer A.; Winter, K.; Okawara, Gordon; Donohue, John H.; Pisters, Peter W.T.; Crane, Christopher H.; Greskovich, J.F.; Anné, Pramila R.; Bradley, Jeffrey D.; Willett, Christopher G.; Rich, Tyvin A.

doi:10.1200/jco.2006.06.4840

Cited by 331 publications

(242 citation statements)

References 7 publications

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“…Recently, the results of the new RTOG 9904 phase II trial in patients with localized gastric adenocarcinoma 44 suggest that preoperative CRT followed by surgery after 5-6 weeks caused a substantial pathological response and a longer survival. Surgery, radiotherapy alone or in combination with chemotherapy all play roles in the treatment of gastric carcinoma.…”

Section: Discussionmentioning

confidence: 99%

The impact of radiotherapy on survival in resectable gastric carcinoma: A meta-analysis of literature data

Fiorica¹,

Cartei²,

Enea

et al. 2007

Cancer Treatment Reviews

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Section: Discussionmentioning

confidence: 99%

The impact of radiotherapy on survival in resectable gastric carcinoma: A meta-analysis of literature data

Fiorica¹,

Cartei²,

Enea

et al. 2007

Cancer Treatment Reviews

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“…The schedule and doses for these regimens have been published elsewhere. 8,9,10 Typical radiation fields encompassed the stomach and regional lymph nodes employing a multiportal technique with customized blocking that included oblique or lateral fields. Thirty-five percent of patients were treated with use of three-dimensional conformal radiation planning.…”

Section: Treatmentmentioning

confidence: 99%

Incidence, Natural History, and Patterns of Locoregional Recurrence in Gastric Cancer Patients Treated With Preoperative Chemoradiotherapy

Reed

Krishnan

Mansfield

et al. 2008

International Journal of Radiation Oncology*Biology*Physics

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Purpose-To retrospectively determine the incidence and patterns (in-field, marginal, or out-offield) of locoregional recurrence of gastric cancer in patients who received preoperative chemoradiotherapy and to determine the outcome in these patients. 1994 and 2004, 149 patients with gastric carcinoma were treated on institutional protocols with preoperative chemoradiation. Ultimately, 105 patients had an R0 resection. Sixty-five of these patients received preoperative chemotherapy followed by chemoradiotherapy and 40 patients received preoperative chemoradiotherapy. Most (96%) of these patients received 5-fluorouracil-based chemotherapy during radiation, and the median dose of Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. Methods and Materials-Between HHS Public Access Author Manuscript Author ManuscriptAuthor Manuscript Author Manuscript radiation administered was 45 Gy. We retrospectively identified and classified the patterns of locoregional recurrences.Results-The 3-year actuarial incidence of locoregional recurrence was 13%, with locoregional disease recurring as any part of the failure pattern in 14 patients. The majority (64%) of evaluable locoregional recurrences were in-field. Two of the four patients with marginal recurrence had inadequate coverage of regional nodal volumes on their oblique fields. The pathologic complete response rate was 23%. A pathologic complete response was the only statistically significant predictor of locoregional control.Conclusions-Patients with gastric cancer who received preoperative chemoradiotherapy had low rates of locoregional recurrence. This strategy merits prospective multi-institutional and randomized evaluation.

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“…High rates of histological complete response (20-30%) have been reported in the American phase II trials [25], but no randomized study has been conducted to date to address the survival benefit of this modality.…”

Section: Neoadjuvant Chemoradiotherapymentioning

confidence: 99%

Japanese gastric cancer treatment guidelines 2010 (ver. 3)

2011

Gastric Cancer

1,998

935

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Phase II Trial of Preoperative Chemoradiation in Patients With Localized Gastric Adenocarcinoma (RTOG 9904): Quality of Combined Modality Therapy and Pathologic Response

Cited by 331 publications

References 7 publications

The impact of radiotherapy on survival in resectable gastric carcinoma: A meta-analysis of literature data

The impact of radiotherapy on survival in resectable gastric carcinoma: A meta-analysis of literature data

Incidence, Natural History, and Patterns of Locoregional Recurrence in Gastric Cancer Patients Treated With Preoperative Chemoradiotherapy

Japanese gastric cancer treatment guidelines 2010 (ver. 3)

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