Phase II study of sunitinib malate, a multitargeted tyrosine kinase inhibitor in patients with relapsed or refractory soft tissue sarcomas. Focus on three prevalent histologies: Leiomyosarcoma, liposarcoma and malignant fibrous histiocytoma

Mahmood, SS; Agresta, Samuel V.; Vigil, Carlos Enrique; Zhao, Xiuhua; Han, Gang; D’Amato, Gina Z.; Calitri, Ciara E.; Dean, Michelle L.; Garrett, Christopher R.; Schell, Michael J.; Antonia, Scott; Chiappori, Alberto

doi:10.1002/ijc.25843

Cited by 105 publications

(78 citation statements)

References 25 publications

(22 reference statements)

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“…In particular, Sunitinib has been used in a phase II study to target the soft tissue sarcoma subtypes leiomyosarcoma, liposarcoma, and malignant fibrous histiocytoma, and it is expected to be effective for the treatment of leiomyosarcoma [15,16]. We ultimately used Axitinib in the current case because of the adverse effects caused by other drugs, rendering them unusable.…”

Section: Discussionmentioning

confidence: 99%

Primary Adrenal Leiomyosarcoma in an Aged Japanese Woman: A Rare Case Report

Aoki¹,

Tanaka²,

Suzuki³

et al. 2017

J Clin Case Rep

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Primary adrenal leiomyosarcoma is an extremely rare tumor. Here, we report the case of a primary adrenal leiomyosarcoma in an 81-year-old woman. Computed tomography showed a right adrenal tumor (7 cm). There were no abnormal findings on physical examination and her serum adrenal hormone levels were normal. However, 67Gallium scintigraphy showed gallium accumulation at the site of a right adrenal tumor, and malignancy was suspected. The right adrenal tumor was surgically removed and histological examination revealed that it was a leiomyosarcoma. After surgical treatment, the patient was administered different types of chemotherapy but she died of local recurrence 1 year later.

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Section: Discussionmentioning

confidence: 99%

Primary Adrenal Leiomyosarcoma in an Aged Japanese Woman: A Rare Case Report

Aoki¹,

Tanaka²,

Suzuki³

et al. 2017

J Clin Case Rep

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“…The first line therapy for retroperitoneal leiomyosarcoma is radical resection, and a tumor that involves large blood vessels may be resected with the vessels, followed by vascular remodeling. Chemotherapy is thought to have no significant effects on patient survival time [4], although a recent report concluded that some patients may experience beneficial effects on sunitinib [5]. Isolated iliac artery aneurysm unaccompanied by abdominal aortic aneurysm is also a rare clinical event [6,7].…”

Section: Discussionmentioning

confidence: 99%

Surgical Treatment for Acute Rupture of Iliac Artery Aneurysm Caused by Invasion of Retroperitoneal Leiomyosarcoma

Zhang¹,

Chen²,

Sun³

et al. 2017

MOJCR

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A 66-year-old female presented with a > 10-year history of hypertension. She began to experienced dull pain in the lower abdomen and abdominal distension two days prior to admission. When she defecated six hours before admission, the pain suddenly aggravated and gradually spread to the whole abdomen, accompanied by dizziness, nausea, and vomiting, as well as symptoms of shock, including prefuse whole-body sweating and chills in all four limbs. Blood pressure was only 74/59 mmHg, she was semilucid with a pained expression, and limbs were wet and cold. Her stomach was distended and felt soft. The whole abdomen was sensitive to applied pressure, particularly the lower abdomen. Abdominal puncture was performed to draw a sample of non-condensable blood. Immediate emergency care included rapid fluid infusion and a blood transfusion. A CT scan revealed an abdominal enhancement consistent with expansion of the right iliac artery and there were masses in the soft tissues adjacent to the common iliac artery. There also appeared to be retroperitoneal hematomas, hence rupture of the aneurysm was suspected (Figure 1). Emergent exploratory laparotomy was performed under general anesthesia, and ≈3000 ml of clotted blood was removed. There was still active bleeding at the site where the pelvic retroperitoneal rupture occurred. Pressure was applied to the site, hematocele was drawn completely. The abdominal aortic branch to the renal lower segment was quickly dissociated and controlled, after which active bleeding decreased significantly. The right iliac artery was expanded significantly to around 3.0 cm in diameter and dilation extended to the initial parts of the common and internal iliac artery. Inside the artery was a solid tumor about 5.0 cm × 5.0 cm × 4.0 cm. The surface of the tumor was ulcerated and bled, its center was necrotized and liquefied and it appeared fish-flesh. The lower border was unclear, and the other extreme was close to the bifurcation of the right common iliac artery (Figure 2). The distal and proximal arteries to the right iliac aneurysm were re-clamped and finely dissociated from around the solid tumor. The distant end of the aneurysm was found to be eroded by ulceration of the solid tumor, forming a laceration about 0.6 cm in diameter. The laceration was connected to the necrotized center of the solid tumor. The bottom of the solid tumor adhered to the pelvic wall. The solid tumor and the right iliac aneurysm were completely resected, and a prosthetic graft (D=8mm, Intervascular) were used to form an end-to-end anastomosis of the common external iliac arteries (Figure 3). Postoperative pathology showed fusocellular sarcoma cells in a fascicular arrangement with high mitotic counts and cytoplasmic acidophilia, consistent with retroperitoneal leiomyosarcoma. Sections of the iliac artery expanded with the tumor and cholesterol crystals were observed in the vessel wall under a microscope. Nearby giant cells reacted with calcification. Postoperative vital signs were fairly stable and the patient recovered ...

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“…Most patients die within 1 year after time of diagnosis because of poor prognosis [5]. No therapeutic protocol has been defined for adjuvant chemotherapy but sunitinib, a tyrosine kinase inhibitor, has been shown to be beneficial in the phase-II studies [6].…”

Section: Discussionmentioning

confidence: 99%

High-Grade Primary Leiomyosarcoma of the Kidney

Ozturk

2014

World J Nephrol Urol

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Leiomyosarcomas account for 0.8 to 2.7% of all malignant renal tumors. Like the leiomyomas, the leiomyosarcomas originate from the cells of the renal capsule, pelvis renalis, the calyces and smooth muscle of the blood vessels. They are two-folds more common in women and most frequently seen in the fourth and sixth decades. They are solitary lesions. Their major symptoms are pain, palpable mass and hematuria. Clinical, radiological and pathological findings of a 51 years old patient presenting with diagnosed flank pain and nausea and diagnosed as having high-grade primary renal leiomyosarcomas were evaluated under the light of current literature.

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Phase II study of sunitinib malate, a multitargeted tyrosine kinase inhibitor in patients with relapsed or refractory soft tissue sarcomas. Focus on three prevalent histologies: Leiomyosarcoma, liposarcoma and malignant fibrous histiocytoma

Cited by 105 publications

References 25 publications

Primary Adrenal Leiomyosarcoma in an Aged Japanese Woman: A Rare Case Report

Primary Adrenal Leiomyosarcoma in an Aged Japanese Woman: A Rare Case Report

Surgical Treatment for Acute Rupture of Iliac Artery Aneurysm Caused by Invasion of Retroperitoneal Leiomyosarcoma

High-Grade Primary Leiomyosarcoma of the Kidney

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