Phase II of the International Study of Asthma and Allergies in Childhood (ISAAC II): rationale and methods

Weiland, Stephan K.; Björkstén, Bengt; Brunekreef, Bert; Cookson, William; Mutius, Erika von; Strachan, David P.

doi:10.1183/09031936.04.00090303

Cited by 380 publications

(371 citation statements)

References 20 publications

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“…The questions on atopic eczema in our study are from the ISAAC study [15], which has been validated in previous worldwide studies [12]. Most of the previous surveys of atopic eczema prevalence have been conducted in Northern Europe [2].…”

Section: Discussionmentioning

confidence: 99%

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Effects of home environment and lifestyles on prevalence of atopic eczema among children in Wuhan area of China

Zhang

Yuan

et al. 2013

Chin. Sci. Bull.

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Section: Discussionmentioning

confidence: 99%

“…The original questionnaire has also been used in Denmark, South Korea, Singapore and USA. The wording for atopic eczema symptoms are from the ISAAC study [15], as shown in Table 1. "Keeping awake at night due to the itchy rash" is defined as severe eczema.…”

Section: The Questionnairementioning

confidence: 99%

Effects of home environment and lifestyles on prevalence of atopic eczema among children in Wuhan area of China

Zhang

Yuan

et al. 2013

Chin. Sci. Bull.

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“…10 All children were asked to withhold all asthma medications for at least 12 hours beforehand. Children with a baseline FEV 1 75% were excluded.…”

Section: Hypertonic Saline Testingmentioning

confidence: 99%

Excessive body weight is associated with additional loss of quality of life in children with asthma

Gent

Ent

Rovers

et al. 2007

Journal of Allergy and Clinical Immunology

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Excessive body weight is associated with additional loss of quality of life in children with asthma van Gent, R.; van der Ent, C.K.; Rovers, M.M.; Kimpen, J.L.L.; Essen-Zandvliet, L.E.M.; de Meer, G. Take-down policy If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum. Background: Asthma and excessive body weight frequently coexist, whereas the exact relationship between the 2 diseases is unknown. Objective: To study whether asthma combined with excessive body weight has a greater effect on quality of life in children than the separate effects of asthma or excessive body weight alone. Methods: In a cross-sectional design, 1758 school children (age 7-10 years) participated: 4 study groups were composed of children with asthma and with/without excessive body weight, and healthy controls with/without excessive body weight. Diagnosis of asthma was defined by either a doctor's diagnosis or by core questions of the International Study of Asthma and Allergies in Childhood questionnaire in combination with either reversible airway obstruction or bronchial hyperresponsiveness. Excessive body weight was defined by using international cutoff points for body mass index. Quality of life was evaluated by the Pediatric Asthma Quality of Life Questionnaire. Results: For all domains of quality of life, children with both asthma and excessive body weight had lower scores than children with either asthma alone or excessive body weight alone. Compared with healthy controls, the score was 25% lower in children with asthma and excessive body weight, 14% lower in children with asthma and normal weight, and only 1% lower in overweight controls. Conclusion: Excessive body weight is associated with an additional decrease in quality of life in children with asthma. Clinical implications: Clinicians should be aware of the interaction between asthma and excessive body weight and the effect on quality of life and should give extra attention to children with both conditions. (J Allergy Clin Immunol 2007;119:591-6.)

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“…Parents of each participating child completed slightly modified versions of questionnaires used in the Collaborative Study on the Genetics of Asthma (11) and the International Study of Asthma and Allergies in Childhood (ISAAC) (12).…”

Section: Questionnairesmentioning

confidence: 99%

Serum Vitamin D Levels and Markers of Severity of Childhood Asthma in Costa Rica

Brehm¹,

Celedón²,

Soto-Quirós³

et al. 2009

Am J Respir Crit Care Med

567

474

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Rationale: Maternal vitamin D intake during pregnancy has been inversely associated with asthma symptoms in early childhood. However, no study has examined the relationship between measured vitamin D levels and markers of asthma severity in childhood. Objectives: To determine the relationship between measured vitamin D levels and both markers of asthma severity and allergy in childhood. Methods: We examined the relation between 25-hydroxyvitamin D levels (the major circulating form of vitamin D) and markers of allergy and asthma severity in a cross-sectional study of 616 Costa Rican children between the ages of 6 and 14 years. Linear, logistic, and negative binomial regressions were used for the univariate and multivariate analyses. Measurements and Main Results: Of the 616 children with asthma, 175 (28%) had insufficient levels of vitamin D (,30 ng/ml). In multivariate linear regression models, vitamin D levels were significantly and inversely associated with total IgE and eosinophil count. In multivariate logistic regression models, a log 10 unit increase in vitamin D levels was associated with reduced odds of any hospitalization in the previous year (odds ratio [OR], 0.05; 95% confidence interval [CI], 0.004-0.71; P 5 0.03), any use of antiinflammatory medications in the previous year (OR, 0.18; 95% CI, 0.05-0.67; P 5 0.01), and increased airway responsiveness (a <8.58-mmol provocative dose of methacholine producing a 20% fall in baseline FEV 1 [OR, 0.15; 95% CI, 0.024-0.97; P 5 0.05]). Conclusions: Our results suggest that vitamin D insufficiency is relatively frequent in an equatorial population of children with asthma. In these children, lower vitamin D levels are associated with increased markers of allergy and asthma severity.For unclear reasons, the prevalence of allergic diseases and asthma increased from a period likely preceding the 1960s to the 1990s (1). Worldwide surveys have shown that asthma prevalence is highest in industrialized nations (2). Although there is a trend for increased prevalence of asthma in countries farthest from the equator, some nations near the equator have high asthma prevalence (e.g., Costa Rica) (2).Results of some, but not all, epidemiologic studies suggest that vitamin D deficiency is associated with an increased incidence of asthma symptoms (3-5). Our group has shown that higher maternal intakes of vitamin D during pregnancy are associated with decreased risks for recurrent wheeze in young children (6, 7), suggesting that vitamin D may play a role in the development of asthma. However, among those with established asthma, vitamin D may have a role in the manifestation of the disorder. Findings from in vitro studies (8) suggest that vitamin D may reverse steroid resistance in individuals with asthma, thus suggesting that vitamin D may play a role in the control of asthma. However, there has been no epidemiologic study of the relation between serum vitamin D levels and markers of asthma severity. The aim of the current analysis, therefore, was to examine the relationship ...

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Phase II of the International Study of Asthma and Allergies in Childhood (ISAAC II): rationale and methods

Cited by 380 publications

References 20 publications

Effects of home environment and lifestyles on prevalence of atopic eczema among children in Wuhan area of China

Effects of home environment and lifestyles on prevalence of atopic eczema among children in Wuhan area of China

Excessive body weight is associated with additional loss of quality of life in children with asthma

Serum Vitamin D Levels and Markers of Severity of Childhood Asthma in Costa Rica

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