Phase II Multicenter, Randomized, Double-Blind Controlled Study of Efficacy and Safety of Umbilical Cord–Derived Mesenchymal Stromal Cells in the Prophylaxis of Chronic Graft-Versus-Host Disease After HLA-Haploidentical Stem-Cell Transplantation

Abstract

Our findings suggest that the repeated infusion of MSCs might inhibit cGVHD symptoms in patients after HLA-haplo HSCT, accompanied by changes in the numbers and subtypes of T, B, and NK cells, leading to the acquisition of immune tolerance.

Donor-derived CAR-T Cells Serve as a Reduced-intensity Conditioning Regimen for Haploidentical Stem Cell Transplantation in Treatment of Relapsed/Refractory Acute Lymphoblastic Leukemia: Case Report and Review of the Literature

“…In our previous clinical practice, MMF and tacrolimus were used from day −7 to prevent GVHD. [19][20][21] In this study, the use of MMF and tacrolimus, which can kill the T cells and thus might be harmful to CAR-T cells, was changed from day −7 to day 1 after the third day of the last infusion of CAR-T cells. This approach was adopted to avoid or alleviate the killing and the inhibition of the proliferation of the CAR-T cells.…”

Umbilical Cord-derived Mesenchymal Stem Cells Instruct Monocytes Towards an IL10-producing Phenotype by Secreting IL6 and HGF

“…Recent studies have provided encouraging results regarding the utility of UC-MSCs in several disease models, such as rescuing visual functions in a rodent model of retinal disease14, alleviating neuropathic pain15, protect against experimental colitis16 and treating rat liver fibrosis1718. The use of UC-MSCs as a cellular therapy is currently being explored in clinical trials, including for the treatment of GvHD1920.…”

Regulatory B cells promote graft-versus-host disease prevention and maintain graft-versus-leukemia activity following allogeneic bone marrow transplantation

“…Although several studies using a mouse bone marrow transplant (BMT) model 9 have identified Tregs, myeloid-derived suppressor cells, and MSCs as available strategies for GVHD alleviation, none of them can be routinely applied in clinic. 10,11 Regulatory B cells (Bregs) are a newly described subset of B cells that appears to play important roles in autoimmunity. [12][13][14][15][16][17] Human Bregs were enriched in both transitional (CD24 …”