Phase II double-blind randomized study comparing oral aloe vera versus placebo to prevent radiation-related mucositis in patients with head-and-neck neoplasms

Su, Catherine K.; Mehta, Vivek; Ravikumar, Lavanya; Shah, Roshni; Pinto, Harlan A.; Halpern, Jerry; Koong, Albert C.; Goffinet, Don R.; Le, Quynh‐Thu

doi:10.1016/j.ijrobp.2004.02.012

Cited by 100 publications

(68 citation statements)

References 22 publications

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“…5C). Iberogast ® in a rat model of chemotherapy induced mucositis study by Biswal et al 32 topical application of honey significantly reduced symptoms of oral mucositis, although, conversely, Su et al 33 reported a negative effect on mean quality of life scores in patients with radiotherapy-induced mucositis following oral administration of aloe-vera. However, patients treated with a wild chamomile mouthwash (Matricaria recutita L, one of the ingredients of Iberogast ® ) relief from oral mucositis was reported.…”

Section: Resultsmentioning

confidence: 96%

The herbal extract Iberogast® improves jejunal integrity in rats with 5-Fluorouracil (5-FU)-induced mucositis

Wright¹,

Yazbeck²,

Lymn³

et al. 2009

Cancer Biology & Therapy

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There is an acute need for the development of effective therapies for mucositis, a debilitating side effect of cancer chemotherapy. Iberogast ® is a herbal extract reported to possess anti-inflammatory properties. We investigated Iberogast ® for its potential to reduce the severity of 5-Fluorouracil (FU)-induced mucositis in rats. Rats were allocated to three treatment groups (n = 8) and gavaged daily with a 10% solution of Iberogast ® or water from day 0 to day 8. Rats were injected intraperitoneally with 5-FU (150 mg/kg) or saline on day 6, and killed after 72 h. In vivo and in vitro sucrase activity was assessed by 13 C-sucrose breath test (SBT) and sucrase assay respectively. Intestinal disease severity was determined by histological assessment of villus height and crypt depth. Significant increases in villus height (277 ± 9 μm) and crypt depth (67 ± 3 μm) were observed in 5-FU + Iberogast ® -treated rats compared with 5-FU + Water (224 ± 13 μm and 48 ± 2 μm respectively; p < 0.05). Sucrase activity was significantly reduced in all 5-FU groups compared to control. Significant reductions in SBT and sucrase activity were observed in all 5-FU groups compared with Saline + Water controls (p < 0.05). We conclude that although Iberogast ® partially improved the histopathological features of 5-FU induced mucositis, it conferred no significant protection as indicated by the assessed endpoints.

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Section: Resultsmentioning

confidence: 96%

The herbal extract Iberogast® improves jejunal integrity in rats with 5-Fluorouracil (5-FU)-induced mucositis

Wright¹,

Yazbeck²,

Lymn³

et al. 2009

Cancer Biology & Therapy

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“…It is claimed to be effective in a variety of applications, but it is potential effect on cancer has been of particular [24] Laboratory Breast cancer Suppressed the proliferation Suboj P et al [25] Laboratory Colon cancer Induced apoptosis Lee HZ et al [26] Laboratory Lung carcinoma Inhibited cell growth in cell lines Chen HC et al [27] Laboratory Promyelocytic leukemia Inhibited cell growth in cell lines Pecere T et al [28] Laboratory Neuroectodermal tumors Inhibited cell growth in cell lines Pan Q et al [29] Laboratory Colorektal cancer Inhibited the angiogenesis through VEGF suppression Yonehara A et al [30] Laboratory Neuroblastoma Suppressing the cyclin D2 transcription level Liu K et al [31] Laboratory Prostate cancer Inhibit cancer cell proliferation by acting through mammalian target of rapamycin complex 2 Heggie S et al [13] Clinical Breast cancer No significant benefit in skin problems caused by radiotherapy Williams MS et al [14] Clinical -No significant benefit in skin problems caused by radiotherapy George J et al [16] Clinical Head and neck cancer Delay the start time of radiotherapy induced skin lesions and reduce their intensity Lissoni P et al [20] Clinical Metastatic cancers Tumor regression Su CK et al [36] Clinical Head and neck cancer No contribution in terms of reducing the symptoms and increasing quality of life interest in recent years. The most advocated benefit of Aloe vera for a cancer patient is its alleged ability to prevent and treat skin lesions caused by radiotherapy.…”

Section: Resultsmentioning

confidence: 99%

“…[35] In another study that enrolled 58 patients with head and neck cancer, the oral administration of Aloe vera made no contribution in terms of reducing symptoms or increasing quality of life (Table 1). [36] …”

Section: Introductionmentioning

confidence: 99%

Aloe Vera and Cancer

Ünlü¹

2016

TJ Oncol

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SUMMARYAloe vera, a succulent plant species, has a long history in folk medicine. Its clear, viscous liquid has been used to treat skin problems and other disorders since ancient times. In the last century, oral consumption and the injection of aloe have also come to popular attention. Its topical use is effective in the treatment of burns and abrasions, and oral use is effective in the treatment of constipation. However, it has not been found to be superior to standard treatments. Most recently, claims of anti-cancer properties are prevalent. It has been found to inhibit proliferation and angiogenesis, and to induce apoptosis in cancer cells. Yet other clinical studies indicate that Aloe vera did not prevent or reduce the number of radiotherapy-related lesions; it merely delayed onset. Furthermore, many instances of toxicity and mortality have been reported in the literature. Today, it is better to avoid it, especially forms taken orally or by injection.

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“…Aloe vera mouthwash did show a nonstatistically significant improvement in quality of life for 58 head and neck cancer patients during radiation treatment, but there was no difference in the number of patients with mucositis, the severity of symptoms, or weight [128]. Utility of chamomile extract mouthwashes was supported in some but not all of the trials.…”

Section: Stomatitis/mucositismentioning

confidence: 91%