Phase I study of Paclitaxel, Cisplatin and 5-fluorouracil combination chemotherapy for unresectable / recurrent gastric cancer

Acid-triggered drug release from micelles based on amphiphilic oligo(ethylene glycol)–doxorubicin alternative copolymers

“…POEGM-DOX was prepared via a Schiff's reaction between POEGM-CHO and DOX$HCl in the presence of TEA. The molecular structure of the POEG 13 M-DOX was conrmed by 1 H NMR (Fig. 1C).…”

“…Recently, numerous anticancer drugs have been discovered for cancer therapy. [1][2][3] However, the clinical outcomes have still been discouraging because of the poor solubility, low tumor selectivity and high systemic toxicity of the anticancer drugs. [4][5][6] Therefore, the search for new and effective treatment strategies is still urgent and necessary.…”

Reduction/pH dual-responsive nano-prodrug micelles for controlled drug delivery

“…[2][3][4] However, these small molecule anticancer drugs are far from perfect because of their poor solubility, severe side effects, rapid elimin-ation and low tumor selectivity in clinical therapy. [5][6][7] Therefore, seeking an effective delivery strategy to increase the drug concentration at the tumor site as well as to reduce the side effects to healthy tissues is urgent and necessary. 8 In recent decades, tremendous efforts have been centered on the design of nano-scaled drug delivery systems, such as nanoparticles, polymeric micelles, dendrimers, liposomes and polymer conjugates for targeted cancer therapy.…”

Efficient Simultaneous Tumor Targeting Delivery of All-Trans Retinoid Acid and Paclitaxel Based on Hyaluronic Acid-Based Multifunctional Nanocarrier

“…1 At present, many drugs such as cisplatin, carboplatin, and 5-fluorouracil have combined with PTX for the combination chemotherapy against cancer. 2,3 It has been reported that the retinoid acid (ATRA), one of the retinoids which inhibits cell proliferation and induces differentiation in a variety of tumor cells, 4 could enhance PTXinduced death of tumor cells and the regression of tumor. 5,6 In the study of Hong et al, the combination of PTX-incorporated pullulan acetate nanoparticles and ATRA-incorporated methoxy poly(ethylene glycol)-grafted chitosan copolymer nanoparticles showed a synergistic antiproliferative effect against CT26 cells.…”

“…Paclitaxel (PTX) is known as the anticancer drugs with significant antitumor activity against a wide variety of tumors such as ovarian carcinoma, breast cancer, nonsmall cell lung cancer, and acute leukemias . At present, many drugs such as cisplatin, carboplatin, and 5-fluorouracil have combined with PTX for the combination chemotherapy against cancer. , It has been reported that the retinoid acid (ATRA), one of the retinoids which inhibits cell proliferation and induces differentiation in a variety of tumor cells, could enhance PTX-induced death of tumor cells and the regression of tumor. , In the study of Hong et al, the combination of PTX-incorporated pullulan acetate nanoparticles and ATRA-incorporated methoxy poly(ethylene glycol)-grafted chitosan copolymer nanoparticles showed a synergistic antiproliferative effect against CT26 cells. Furthermore, the activity of MMP-2, a key enzyme in tumor cell invasion, was significantly decreased in cells treated with the combination of PTX and ATRA .…”