Phase I/II Trial of External Irradiation plus Medium-Dose Brachytherapy Given Concurrently to Liposomal Doxorubicin and Cisplatin for Advanced Uterine Cervix Carcinoma

Abstract

The MTD of Caelyx given concurrently with CDDP and RT was determined at the 12 mg/m2/week dose level. The above CCRT schema is a well-tolerated regimen, easy to administer in ambulatory patients, and results appear promising.

Radiotherapy versus Concurrent 5-Day Cisplatin and Radiotherapy in Locally Advanced Cervical Carcinoma

“…A recent study showed that concomitant RTCT with cisplatin and liposomal doxorubicin is a promising and well-tolerated regimen in patients with advanced cervical cancer [22]. Taken together, these data provide consistent evidence of benefit for the two-drug regimen.…”

Lymph Edema of the Lower Extremities after Lymphadenectomy and Radiotherapy for Cervical Cancer

“…Tumor involvement in pelvic or paraaortic lymph nodes represents the most important prognostic factor in patients with cervical cancer [6,8,9,19,20,36]. In order to get the most reliable information upon the nodal status, thus, a large number of lymph nodes with a mean from 20 to 30 is removed [3,13,17,18,20,28].…”

Optimized Conformal Paraaortic Lymph Node Irradiation is not Associated with Enhanced Renal Toxicity

“…For patients with gynecologic carcinomas, radiation therapy of tumor-involved paraaortic lymph nodes (PLNs) is a routine treatment concept [16,29]. In cervical cancer patients, the presence of metastatic spread to the PLNs correlates with poor prognosis.…”