Phase I/II Multiinstitutional Study of Uterine Artery Embolization with Gelatin Sponge for Symptomatic Uterine Leiomyomata: Japan Interventional Radiology in Oncology Study Group Study

Uterine artery embolization by use of porous gelatin particles for symptomatic uterine leiomyomas: comparison with hand-cut gelatin sponge particles

“…Minor complications (SIR class A), including transient elevation in AST and ALT, were comparable with those reported by Sone et al [14]. The mean post-procedure pain score was 9.3 after use [19].…”

“…Thus, UAE was performed with hand-cut gelatin sponge [14,15] between July 2002 and December 2006; then, after February 2007, PGS was used as the embolic material. PGP was supplied as 1 or 2-mm dry particles in bottles, in a form ready for use when mixed with diluted contrast material.…”

“…Each patient was provided with a self-administered set of questionnaires for assessment of symptom change score ranging from 0 (marked worsening) to 10 (marked improvement) on a scale on which 5 represented no change, and these were submitted at the follow-up visits 1, 3, 6 and 12 months after UAE. Symptom improvement was classified into three categories: marked improvement (score 8 and over), moderate improvement (score over 5 and lower than 8), and no improvement (score 5 or lower) [14]. Ovarian function was assessed on the basis of the presence or absence of menstruation after UAE.…”

Uterine Artery Embolization for Symptomatic Leiomyomata

“…Although there was a trend towards greater uterine and dominant fibroid volume reductions with TAGM compared with spherical PVA, the difference was not statistically significant (Level 2A) [26][27][28][29][30][31][32][33].…”

“…It is also important to note that pain is usually not experienced during the procedure but may begin in the immediate post-UAE period and is most intense during the first 24 h after UAE with a peak around 7 h [32,[34][35][36][37].…”