Phase formation and evolution in the silicon substituted tricalcium phosphate/apatite system

Reid, Joel W.; Pietak, Alexis; Sayer, M.; Dunfield, D.; Smith, Thomas

doi:10.1016/j.biomaterials.2004.09.005

Cited by 139 publications

(123 citation statements)

References 5 publications

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“…Inorganic matter is referring to bone minerals, and includes the crystalline hydroxyapatite and amorphous colloidal calcium phosphorus. Collagenous fibers are matrix proteins that constitute the bone structure and maintain the bone mechanical strength (25). Thus, bone formation is equivalent to bone mineralization, and refers to the process through which amorphous calcium phosphate and its bone mineral are deposited in bone organic matter intervals regularly (26).…”

Section: Discussionmentioning

confidence: 99%

Protective effects of resveratrol on osteoporosis via activation of the SIRT1‑NF‑κB signaling pathway in rats

2017

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Abstract. The aim of the present study was to determine the protective effects of resveratrol on a rat model of osteoporosis and examine the associated mechanisms of its action. Rats were randomized into the following groups: Control, osteoporosis, osteoporosis + low-dose resveratrol, osteoporosis + middle-dose resveratrol and osteoporosis + high-dose resveratrol groups. Resveratrol treatment was administered 7 days after surgery for 8 weeks. ELISA assay was used to analyze alkaline phosphatase (ALP) and osteocalcin (OC) protein levels. Western blotting was performed to assess the protein expression of sirtuin 1 (SIRT1), nuclear factor (NF)-κB and NF-κB inhibitor (IkB) α. In the present study, the results indicated that resveratrol markedly improved the bone mineral density value, femoral porosity and bone mechanical tests in osteoporosis rats. Administration of resveratrol significantly decreased the serum levels of ALP and OC in rats with osteoporosis. Finally, treatment with resveratrol significantly promoted the protein expression of SIRT1, suppressed NF-κB and activated the IkBα protein expression in rats with osteoporosis. In conclusion, treatment with resveratrol significantly improved the final body weight of the osteoporosis rats via the SIRT1-NF-κB signaling pathway. The present study suggested that resveratrol exerted a protective effect on osteoporosis through activation of the SIRT1-NF-κB signaling pathway in rats.

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Section: Discussionmentioning

confidence: 99%

Protective effects of resveratrol on osteoporosis via activation of the SIRT1‑NF‑κB signaling pathway in rats

2017

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“…Namely, at the turn of the millennium, the previously forgotten data that the presence of silicates stabilized a-TCP at temperatures of 800-1000°C (Nurse et al 1959) were rediscovered again. Such type of a-TCP is called ''silica stabilized a-TCP'' (Sayer et al 2003;Reid et al 2005Reid et al , 2006. Furthermore, sometimes, a-TCP might be prepared at even lower temperatures (*700°C) by a thermal decomposition of low-temperature ACPs (Kanazawa et al 1982).…”

Section: A-tcpmentioning

confidence: 99%

“…The disadvantage for using a-TCP is its quick resorption rate (faster than formation of a new bone), which limits its application in this area. However, the silicon stabilized a-TCP (more precisely as a biphasic composite with HA) has been commercialized as a starting material to produce bioresorbable porous ceramic scaffolds to be used as artificial bone grafts (Sayer et al 2003;Reid et al 2005Reid et al , 2006. Upon implantation, a-TCP tends to convert to CDHA, which drastically reduces further degradation rate.…”

Section: A-tcpmentioning

confidence: 99%

“…Presently, commercial BCP products of different or similar HA/b-TCP ratios are manufactured in many parts of the world as bone graft or bone substitute materials for orthopedic and dental applications under various trademarks and several manufacturers (Dorozhkin 2012d). A similar combination of a-TCP with HA forms BCP as well (Reid et al 2005;Pan et al 2006;Kui 2007;Li et al 2009b).…”

Section: Biphasic Triphasic and Multiphasic Capo 4 Formulationsmentioning

confidence: 99%

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Calcium orthophosphates (CaPO 4 ): Occurrence and properties

Dorozhkin¹

2017

Morphologie

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“…Small amounts of β-TCP were also detected. The β-TCP content in α-TCP was 8 wt % and diminished to only 4 wt % in Si-α-TCP, thus confirming the efficacy of silicon doping in stabilizing the α-TCP crystalline phase, even at lower temperatures [27].…”

Section: Accepted Manuscriptmentioning

confidence: 64%

Influence of Si substitution on the reactivity of α-tricalcium phosphate

Motisuke

Mestres

Renó

et al. 2017

Materials Science and Engineering: C

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Silicon substituted calcium phosphates have been widely studied over the last ten years due to their enhanced osteogenic properties. Notwithstanding, the role of silicon on α-TCP reactivity is not clear yet. Therefore, the aim of this work was to evaluate the reactivity and the properties of Si-α-TCP in comparison to α-TCP. Precursor powders have similar properties regarding purity, particle size distribution and specific surface area, which allowed a better comparison of the Si effects on their reactivity and cements properties. Both Si-α-TCP and α-TCP hydrolyzed to a calcium-deficient hydroxyapatite when mixed with water but their conversion rates were different. Si-α-TCP exhibited a slower setting rate than α-TCP, i.e. k SSA for Si-TCP (0.021 g.m -2 .h -1 ) was almost four times lower than for α-TCP (0.072 g.m -2 .h -1 ). On the other hand, the compressive strength of the CPC resulting from fully reacted Si-α-TCP was significantly higher (12.80± 0.38 MPa) than that of α-TCP (11.44 ± 0.54 MPa), due to the smaller size of the entangled precipitated apatite crystals.

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Phase formation and evolution in the silicon substituted tricalcium phosphate/apatite system

Cited by 139 publications

References 5 publications

Protective effects of resveratrol on osteoporosis via activation of the SIRT1‑NF‑κB signaling pathway in rats

Protective effects of resveratrol on osteoporosis via activation of the SIRT1‑NF‑κB signaling pathway in rats

Calcium orthophosphates (CaPO 4 ): Occurrence and properties

Influence of Si substitution on the reactivity of α-tricalcium phosphate

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