Phase Distribution Studies on an Oil—Water Emulsion Based on a Eutectic Mixture of Lidocaine and Prilocaine as the Dispersed Phase

Tuning molecular dynamics by hydration and confinement: antiplasticizing effect of water in hydrated prilocaine nanoclusters

“…Avoiding phase transformation or change in physico-chemical properties during storage of a drug or of a formulation is vital, as is providing a drug formulated in a phase that can be easily absorbed by the body and is compatible with an aqueous medium. Studying the dynamics of glassy drugs and their interaction with water provides relevant information not aminoamide local anesthetic often used in dentistry, which shows maximum hydration at a mole fraction of x H 2 O = 0.33 [17][18][19] . The addition of more water to the system separates the solution into two stable liquid phases: a prilocaine-rich liquid with minority water content (liquid L 1 , x = 0.33 ± 0.02, with approximately two molecules of prilocaine for every H 2 O), and a very dilute waterbased solution of prilocaine (liquid L 2 , x = 0.98 ± 0.01, with approximately one molecule of prilocaine for every 99 molecules of H 2 O).…”

Characterization and Comparison of Lidocaine-Tetracaine and Lidocaine-Camphor Eutectic Mixtures Based on Their Crystallization and Hydrogen-Bonding Abilities

“…However, owing to the toxic side effects of cocaine and the caustic properties of phenol, this mixture was seldom used. Later on, an emulsion containing equal amounts of lidocaine and prilocaine, called EMLA (eutectic mixture of local anesthetics) cream, was used for topical anesthesia (11)(12)(13). In a study, the EMLA cream was found to be more effective compared to a bonain mixture for eardrum anesthesia (14).…”

Interactions between Local Anaesthetic Agents and Poly(N-isopropyl acrylamide) through Phase Behavior, Surface Tension, and Adsorption Measurement

“…11678-01, and lidocaine, batch no. 58549-01, were kindly provided by AstraZeneca R&D, Södertälje, Sweden and were used as received (45)(46)(47). Lysozyme, L6876, was purchased from Sigma Chemical Co., St. Louis, MI and then dialyzed in a tube with a molecular weight cutoff of 6000-8000 at +5…”