Phase dependent encapsulation and release profile of ZIF-based biocomposites

Abstract

We report two ternary phase diagrams that show the synthesis conditions to prepare protein@ZIF biocomposites with different phases, including BSA@ZIF-C and insulin@ZIF-C. For each biocomposite, we measured distinct encapsulation efficiency and release profile properties.

Can 3D electron diffraction provide accurate atomic structures of metal–organic frameworks?

“…The structure of BSA@ZIF-CO3-1 is shown in Figure 5. In addition to Zn(II) cation and mIM ions, carbonate ions CO3 2are also found in the structure, which is evident by FTIR and Raman spectra as well 54 .…”

“…The BSA@ZIF-CO3-1 was discovered during the study of phase dependent encapsulation and release of ZIF-based biocomposites. 54 In detail, 300 μL of a 440 mM aqueous solution of 2methylimidazole, HmIM (TCI Chemicals), 60 μL of a 36 mg/ml aqueous solution of BSA (lyophilized powder, Sigma-Aldrich) and 1140 μL of deionized water were mixed in a 2 ml plastic centrifuge tube for 1 minute. Then, this solution was added to 500 μL of a 80 mM aqueous solution of Zn(OAc)2•2(H2O) (EMSURE, Merck).…”

Three-dimensional electron diffraction for porous crystalline materials: structural determination and beyond

“…Therefore, it is much easier to perform ab initio structure determination on nano-and submicron-sized MOFs nowadays. 40,41,[73][74][75][76][77][78][79][80][81][82][83][84][85] The revealed structural details provide an enhanced understanding of their properties as well as fundamental knowledge to promote the discovery of new materials.…”

In situ assembled ZIF superstructures via an emulsion-free soft-templating approach

“…[26][27][28][29][30] Zeolitic imidazolate frameworks (ZIFs) are a well-known subclass of MOFs as they are topologically isomorphic to zeolites and have recently been extensively used in biomedical applications due to their biocompatibility. [31][32][33][34] ZIF-8, in particular, has been extensively used for drug delivery, biomimetic mineralization and sheltering of biomacromolecules. [35][36][37][38][39][40][41] Hollow ZIF-8 and HKUST-1 colloidosomes were prepared via an emulsion-based so interfacial formation method.…”