Phase controlled one-pot synthesis of heterostructured FePt–Fe₃O₄ nanocubes with excellent biocompatibility

Abstract

We demonstrated a simple one-pot synthesis approach for the controlled composition of homogeneous FePt and phase-controlled heterostructured FePt/Fe3O4 nanocubes (NCs) utilizing 1,2-hexadecanediol and 1-octadecene as the reducing agents, respectively.

Synthetic Approaches to Colloidal Nanocrystal Heterostructures Based on Metal and Metal-Oxide Materials

“…As each construction step was induced and promoted in a specific range of temperatures, adjustment of the heating ramp allowed the two sections of the CNHSs to evolve at distant times during the heating period. These CNHSs were found to be biocompatible [ 298 ] Because of the exchange-spring coupling setting through the heterointerface between FePt and Fe x O y , the CNHSs manifested not only the typical magnetic response of a single magnetic phase, but also enhanced MRI contrast-agent properties, relative to those of the single constituents [ 297 ].…”

Magnetically guided theranostics: montmorillonite-based iron/platinum nanoparticles for enhancing in situ MRI contrast and hepatocellular carcinoma treatment

“…The authors then used the solvent exchange to coat the FePt@MnO particles to enhance the signal of MRI. Emo et al used a double iron-based model, FePt@Fe 3 O 4 nanoparticles, to treat leukemia [ 4 ]. This nanocomposite with PEG chains can increase the internalization ratio of nanoparticles, prompt the therapeutic effect, improve the image contrast of tumors, and induce tumor cell death through local temperature increases.…”

“… FePt-Fe 3 O 4 nanocubes 10–13 nm 26.5 emu·g −1 n/a THP-1 cell line Emo et al . [ 4 ] FePt@Kaolinite nanocomposites 100 ± 10 nm 25.86 emu g −1 17.18 mM −1 s −1 (4.7 T) HepG2 cell line Chan et al . [ 5 ] FePt@MnO nanoparticles 8 ± 1 nm n/a 8.14 mM −1 s −1 (3 T) HepG2 cell line MCF-7 cell line Yang et al .…”