Phase-controlled intermittent intratracheal insufflation of oxygen during chest compression-active decompression mCPR improves coronary perfusion pressure over continuous insufflation

Abstract

Phase-controlled intermittent intratracheal insufflation of oxygen during chest compression-active decompression mCPR improves coronary perfusion pressure over continuous insufflation

Advantage of new ventilation method for cardiopulmonary resuscitation qualitatively captured by simple respiratory mechanics models

“…Therefore, the oxygen source is modelled as an ideal voltage source V in . A resistor in series with V in represents the resistance of the narrow channels with a value R BT , calculated according to experimental pressures and flows from [8]. In the case of CIO, V in is constant at a value equivalent to the pressure regulator setting of 2.5 bar.…”

“…They are therefore represented as a voltage source in series with the the lung capacitor C in the RIC model and the chest wall capacitor C W in the Mead model. The voltage was varied in a trapezoidal waveform with 100 ms flanks representing the constant speed of the mCPR device's piston used in the preclinical experiment [8]. The waveform was given a 50 % duty cycle, 600 ms period, and 200 ms delay relative to the oxygen insufflation waveform.…”

“…The experimental data used here was published in [8], where the experimental protocol is described in detail. Twenty Swedish domestic pigs, 25-30 kg in weight, were used following the Utstein-style guidelines for CPR research Fig.…”

“…The dynamics of the lungs and thorax have a low-pass effect on changes in lung volume due to oxygen insufflation. Phase-controlled intermittent insufflation of oxygen (PIIO), introduced in [8] and defined in Fig. 4, was suggested as a means to account for these dynamics.…”

“…Intratracheal pressure is shown as P trachea . has shown that PIIO results in higher CPP and compression phase aortic pressure than CIO [8]. The electronic controller developed for coordinating PIIO is shown in Fig.…”