“…In light of these fundamental difficulties, additional limiting assumptions were frequently employed, for example, lattice models, enabling treatments of up to 1025 molecules. Of course, instead of discretizing space into a lattice model, it is also possible to achieve significant speed‐ups in a continuous‐space approach, by restricting the molecular models themselves, for example, employing coarse‐grained force‐fields, fully rigid molecules and linearly interpolated forces, or other highly simplified descriptions, again enabling treatments of up to 1200 molecules.…”