Phase Behavior of Polymers in Supercritical Fluid Solvents

Kirby, Christopher F.; McHugh, Mark A.

doi:10.1021/cr970046j

Cited by 367 publications

(388 citation statements)

References 195 publications

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“…Below this pressure value, solubility increases with decreasing temperature, and above 12.0 MPa, the effect of the temperature on the solute vapor pressure overlays the effect on the solvent density, resulting in an increase of the solubility with the temperature increase. The ethanol cosolvent effect on flurbiprofen's solubility in supercritical CO 2 The solubility results obtained in this work are very promising for the development of supercritical processes for pharmaceutical applications based on this drug.…”

Section: Discussionmentioning

confidence: 76%

“…Some CDRSs and other medical applications have been developed using techniques involving SC CO 2 . [1][2][3][4][5][6][7][8] The design of chemical and pharmaceutical processes based on SCFs and the determination of their best operating conditions requires a knowledge of phase equilibria and drug solubility in a supercritical fluid. In the last two decades, solubility in SCFs of a large number of different low-volatility compounds have been measured, reported, and reviewed.…”

Section: Introductionmentioning

confidence: 99%

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Solubility of Flurbiprofen in Supercritical Carbon Dioxide

et al. 2004

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Equilibrium solubility of flurbiprofen, a nonsteroidal antiinflammatory agent, in supercritical carbon dioxide was measured by a static analytical method in the pressure range from (8.0 to 25.0) MPa, at temperatures of (303.0, 313.0, and 323.0) K. The cosolvent effect of ethanol in the solubility of the bioactive compound in supercritical carbon dioxide was investigated at 18 MPa and 313 K. The results obtained have a potential application in supercritical processes for this drug. Experimental solubility data were correlated with an empirical density-based Chrastil model.

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Section: Discussionmentioning

confidence: 76%

Section: Introductionmentioning

confidence: 99%

Solubility of Flurbiprofen in Supercritical Carbon Dioxide

et al. 2004

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“…It is considered that increasing the initial pressure and changing the side chain of D4 will increase the solubility of the monomer in scCO 2 . [20][21][22][23][24] The amount of impregnated low-molecular-weight components also depends on the soaking time and it attains an Figure 1 Synthetic scheme for preparation of PDMS.…”

Section: Resultsmentioning

confidence: 99%

Surface properties and depth analysis of polyethylene/polydimethylsiloxane composite prepared by using supercritical carbon dioxide

Zhu

Hoshi

Sasaki³

et al. 2010

Polym J

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Blends of polyethylene (PE) and polydimethylsiloxane (PDMS) are usually immiscible and have phase-separated morphology. In this study, the polymer composite comprising PE and PDMS with a hydrophobic surface was developed. This composite was obtained by a synthetic method using supercritical carbon dioxide. Results of X-ray photoelectron spectroscopy and attenuated total reflection Fourier-transform infrared spectroscopy indicated that PDMS was located on the surface of the PE substrate. Scanning electron microscope-energy-dispersive X-ray (SEM-EDX) measurement provided the depth information indicating that PDMS existed in the PE substrate. Water contact angle measurement revealed that the hydrophobicity of PE had been improved from 94 to 1051 by incorporating PDMS.

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“…Unfortunately, no solubility data for these two polymers in supercritical CO 2 could be found in the literature, but it was assumed that their solubility was extremely limited. Therefore, acetone (99.5%, Fisher, France) was chosen as a cosolvent since it is widely used to increase polymer solubility by improving dispersion, inducing dipolar interactions and by increasing the solvent density [35]. Monodisperse spherical glass beads with diameters of 315 and 500 Am (Potters-Ballotini, France) were chosen as host particles.…”

Section: Methodsmentioning

confidence: 99%

Extraction and precipitation particle coating using supercritical CO2

et al. 2002

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A modified RESS process for particle coating with a solution of polymer in supercritical CO 2 was studied in this research. This technique involves extracting the polymer with supercritical CO 2 , with or without a cosolvent in an extraction vessel, and then precipitating the polymer onto the surface of host particles in a second precipitation vessel by adjusting the pressure and temperature inside the precipitator to lower its solubility. The research was performed using a pilot-scale supercritical apparatus, glass beads as host particles and two different polymers as coating materials. Experiments showed that the coating of glass beads with polyvinyl chloride-co-vinyl acetate (PVCVA) and hydroxypropyl cellulose (HPC) was successfully achieved. Scanning electron microscopy (SEM), energy dispersive X-ray spectrometry (EDS), energy dispersive X-ray mapping and thermogravimetric analysis (TGA) were used to characterize the coatings obtained. The results indicate that the process of particle coating with supercritical solution is a promising environmentally friendly, alternative coating method with little or no organic solvents required.

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Phase Behavior of Polymers in Supercritical Fluid Solvents

Cited by 367 publications

References 195 publications

Solubility of Flurbiprofen in Supercritical Carbon Dioxide

Solubility of Flurbiprofen in Supercritical Carbon Dioxide

Surface properties and depth analysis of polyethylene/polydimethylsiloxane composite prepared by using supercritical carbon dioxide

Extraction and precipitation particle coating using supercritical CO2

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